Mathieu Coureuil

mathieu.coureuil@inserm.fr
https://orcid.org/0000-0001-7655-9685
ResearchGate

Mathieu Coureuil is group leader in the team.
MC is a senior scientist at the Necker-Enfants Malades Institute (« Chargé de Recherche », Inserm). He received his Ph.D. in Cell Biology from University Paris-Sud, France, in 2006. Since then, he studies the interaction between N. meningitidis and human endothelial cells. He demonstrated the role of the meningococcus induced endothelial cell signaling during invasion of human vessels.  His current discovery-driven research focuses on determining the molecular mechanisms involved in the endothelial cell colonization. Besides, Mathieu Coureuil developed a new thematic studying S. aureus in the context of chronic infections.

Currently, MC is interested in invasive meningococcal infections, from portal of entry to sepsis, as well as chronic S. aureus infections.

Last News of the Lab

Airway environment promote Staphylococcus aureus chronic lifestyle

11/12/2023Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyleXiongqi Ding et al. Nat Commun 2023 Staphylococcus aureus is a predominant cause of chronic lung infections. While the airway environment is rich in highly sialylated mucins, the interaction of S. aureus with sialic acid is poorly characterized. Using S. aureus USA300 as well as clinical isolates, we ...
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Grant ANR PRC and PRME

24/07/2023 .Emmanuelle Bille was granted ANR PRME for her project on N. meningitidis and filamentous phage biology. The Neisseria group was also granted ANR PRC in collaboration with Sandrine Bourdoulous. Partnership Between Filamentous Phages and Type IV Pili in virulent meningococci (PaPi) The overall objective of our project is to decipher the partnership between the ...
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Congratulation to Morgane Wuckelt and Elif UYAR

24/07/2023 .Morgane Wuckelt and Elif Uyar have been awarded a PhD Track Grant from BioSPC. We are all very proud and very excited about the science to come. Morgane will work on Neisseria meningitidis and Type IV Pili. Elif will work on Staphylococcus aureus adaptation to chronic infections ...
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Team Members (Neisseria meningitidis)

Last 25 Publications

  1. Sereme, Y, Schrimp, C, Faury, H, Agapoff, M, Lefebvre-Wloszczowski, E, Chang Marchand, Y et al.. A live attenuated vaccine to prevent severe neonatal Escherichia coli K1 infections. Nat Commun. 2024;15 (1):3021. doi: 10.1038/s41467-024-46775-x. PubMed PMID:38589401 PubMed Central PMC11001983.
  2. Rytter, H, Roger, K, Chhuon, C, Ding, X, Coureuil, M, Jamet, A et al.. Dual proteomics of infected macrophages reveal bacterial and host players involved in the Francisella intracellular life cycle and cell to cell dissemination by merocytophagy. Sci Rep. 2024;14 (1):7797. doi: 10.1038/s41598-024-58261-x. PubMed PMID:38565565 PubMed Central PMC10987565.
  3. Ding, X, Robbe-Masselot, C, Fu, X, Léonard, R, Marsac, B, Dauriat, CJG et al.. Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle. Nat Commun. 2023;14 (1):8135. doi: 10.1038/s41467-023-43863-2. PubMed PMID:38065959 PubMed Central PMC10709412.
  4. Wu, S, Coureuil, M, Nassif, X, Tautz, L. NMA1982 is a Novel Phosphatase and Potential Virulence Factor in Neisseria meningitidis. bioRxiv. 2023; :. doi: 10.1101/2023.05.23.541968. PubMed PMID:37292688 PubMed Central PMC10245925.
  5. Schönherr-Hellec, S, Chatzopoulou, E, Barnier, JP, Atlas, Y, Dupichaud, S, Guilbert, T et al.. Implantation of engineered human microvasculature to study human infectious diseases in mouse models. iScience. 2023;26 (4):106286. doi: 10.1016/j.isci.2023.106286. PubMed PMID:36942053 PubMed Central PMC10024136.
  6. Ding, X, Fu, X, Euphrasie, D, Ferroni, A, Sermet-Gaudelus, I, Charbit, A et al.. Genomic analysis of Staphylococcus aureus sequential isolates from lungs of patients with cystic fibrosis. Microbes Infect. 2023;25 (6):105124. doi: 10.1016/j.micinf.2023.105124. PubMed PMID:36871931 .
  7. Marullo, S, Scott, MGH, Enslen, H, Coureuil, M. Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe Can Reveal Signalling Pathways in Endothelial Cells, and a Unique Mode of Receptor Activation Involving Its N-Terminal Glycan Chains. Front Endocrinol (Lausanne). 2022;13 :883568. doi: 10.3389/fendo.2022.883568. PubMed PMID:35586623 PubMed Central PMC9108228.
  8. Ramond, E, Lepissier, A, Ding, X, Bouvier, C, Tan, X, Euphrasie, D et al.. Lung-Adapted Staphylococcus aureus Isolates With Dysfunctional Agr System Trigger a Proinflammatory Response. J Infect Dis. 2022;226 (7):1276-1285. doi: 10.1093/infdis/jiac191. PubMed PMID:35524969 .
  9. Barroca, V, Racine, C, Pays, L, Fouchet, P, Coureuil, M, Allemand, I et al.. The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice. Stem Cell Res. 2022;60 :102723. doi: 10.1016/j.scr.2022.102723. PubMed PMID:35247845 .
  10. Barnier, JP, Meyer, J, Kolappan, S, Bouzinba-Ségard, H, Gesbert, G, Jamet, A et al.. The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci U S A. 2021;118 (45):. doi: 10.1073/pnas.2109364118. PubMed PMID:34725157 PubMed Central PMC8609321.
  11. Rytter, H, Jamet, A, Ziveri, J, Ramond, E, Coureuil, M, Lagouge-Roussey, P et al.. The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella. PLoS Pathog. 2021;17 (8):e1009326. doi: 10.1371/journal.ppat.1009326. PubMed PMID:34339477 PubMed Central PMC8360588.
  12. Ramond, E, Jamet, A, Ding, X, Euphrasie, D, Bouvier, C, Lallemant, L et al.. Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the Drosophila Larval Model. mBio. 2021;12 (3):e0027621. doi: 10.1128/mBio.00276-21. PubMed PMID:34126772 PubMed Central PMC8262968.
  13. Barnier, JP, Euphrasie, D, Join-Lambert, O, Audry, M, Schonherr-Hellec, S, Schmitt, T et al.. Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model. PLoS Pathog. 2021;17 (2):e1009299. doi: 10.1371/journal.ppat.1009299. PubMed PMID:33592056 PubMed Central PMC7909687.
  14. Rytter, H, Jamet, A, Coureuil, M, Charbit, A, Ramond, E. Which Current and Novel Diagnostic Avenues for Bacterial Respiratory Diseases?. Front Microbiol. 2020;11 :616971. doi: 10.3389/fmicb.2020.616971. PubMed PMID:33362754 PubMed Central PMC7758241.
  15. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 PubMed Central PMC8106705.
  16. Marullo, S, Doly, S, Saha, K, Enslen, H, Scott, MGH, Coureuil, M et al.. Mechanical GPCR Activation by Traction Forces Exerted on Receptor N-Glycans. ACS Pharmacol Transl Sci. 2020;3 (2):171-178. doi: 10.1021/acsptsci.9b00106. PubMed PMID:32296760 PubMed Central PMC7155188.
  17. Dos Santos Souza, I, Maïssa, N, Ziveri, J, Morand, PC, Coureuil, M, Nassif, X et al.. Meningococcal disease: A paradigm of type-IV pilus dependent pathogenesis. Cell Microbiol. 2020;22 (4):e13185. doi: 10.1111/cmi.13185. PubMed PMID:32185901 .
  18. Le Guennec, L, Virion, Z, Bouzinba-Ségard, H, Robbe-Masselot, C, Léonard, R, Nassif, X et al.. Receptor recognition by meningococcal type IV pili relies on a specific complex N-glycan. Proc Natl Acad Sci U S A. 2020;117 (5):2606-2612. doi: 10.1073/pnas.1919567117. PubMed PMID:31964828 PubMed Central PMC7007569.
  19. Audry, M, Robbe-Masselot, C, Barnier, JP, Gachet, B, Saubaméa, B, Schmitt, A et al.. Airway Mucus Restricts Neisseria meningitidis Away from Nasopharyngeal Epithelial Cells and Protects the Mucosa from Inflammation. mSphere. 2019;4 (6):. doi: 10.1128/mSphere.00494-19. PubMed PMID:31801841 PubMed Central PMC6893211.
  20. Tan, X, Coureuil, M, Charbit, A, Jamet, A. Multitasking Actors of Staphylococcus aureus Metabolism and Virulence. Trends Microbiol. 2020;28 (1):6-9. doi: 10.1016/j.tim.2019.10.013. PubMed PMID:31753539 .
  21. Ramond, E, Jamet, A, Coureuil, M, Charbit, A. Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens. Front Immunol. 2019;10 :2461. doi: 10.3389/fimmu.2019.02461. PubMed PMID:31708919 PubMed Central PMC6819784.
  22. Le Guennec, L, Coureuil, M, Nassif, X, Bourdoulous, S. Strategies used by bacterial pathogens to cross the blood-brain barrier. Cell Microbiol. 2020;22 (1):e13132. doi: 10.1111/cmi.13132. PubMed PMID:31658405 .
  23. Virion, Z, Doly, S, Saha, K, Lambert, M, Guillonneau, F, Bied, C et al.. Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili. Nat Commun. 2019;10 (1):4752. doi: 10.1038/s41467-019-12685-6. PubMed PMID:31628314 PubMed Central PMC6800425.
  24. Ziveri, J, Chhuon, C, Jamet, A, Rytter, H, Prigent, G, Tros, F et al.. Critical Role of a Sheath Phosphorylation Site On the Assembly and Function of an Atypical Type VI Secretion System. Mol Cell Proteomics. 2019;18 (12):2418-2432. doi: 10.1074/mcp.RA119.001532. PubMed PMID:31578219 PubMed Central PMC6885697.
  25. Tan, X, Ramond, E, Jamet, A, Barnier, JP, Decaux-Tramoni, B, Dupuis, M et al.. Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection. J Infect Dis. 2019;220 (12):1967-1976. doi: 10.1093/infdis/jiz404. PubMed PMID:31420648 .
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