Emmanuelle Bille

Emmanuelle Bille is leader of the thematic Filamentous Phage in the Neisseria team.
EB is a pharmacist and microbiologist (phD, PD). She is an associate professor (MCU-PH) in the Unit of « Pathogenesis of Systemic Infections » (U1151-E7, INEM, Paris) and an academic practitioner in the Microbiology Laboratory of the Necker Children’s Hospital.
Besides her hospital activities at the Necker-Enfants Malades Hospital, she has pursued fundamental research activities on Neisseriameningitidis virulence since 2003. Emmanuelle Bille highlighted a filamentous bacteriophage, designated MDAΦ for Meningococcal Disease Associated, associated with invasive diseases caused by N. meningitidis. The presence of the prophage MDA in the genome of a strain, via the production of viruses, increases colonization of meningococci onto monolayers of epithelial cells. So, MDAΦ seems increase bacterial colonization in the mucosa at the site-of-entry, and increase the occurrence of diseases.

We are member of the Bacteriophage Network France : https://site.phages.fr/

Last News of the Lab

Grant ANR PRC and PRME

24/07/2023 .Emmanuelle Bille was granted ANR PRME for her project on N. meningitidis and filamentous phage biology. The Neisseria group ...
Lire La Suite…

Congratulation to Morgane Wuckelt and Elif UYAR

24/07/2023 .Morgane Wuckelt and Elif Uyar have been awarded a PhD Track Grant from BioSPC. We are all very proud ...
Lire La Suite…

Engineered human microvasculature to study human infectious diseases

27/03/2023 . Implantation of engineered human microvasculature to study human infectious diseases in mouse models.Sophia Schönherr-Hellec et al iScience 2023 ...
Lire La Suite…

Team Members

Last Publications

  1. Faury, H, Stanzelova, A, Ferroni, A, Belhous, K, Morand, P, Toubiana, J et al.. Mycobacterium canettii Tuberculosis Lymphadenopathy in a 3-Year-old Child. Pediatr Infect Dis J. 2023;42 (9):e345-e347. doi: 10.1097/INF.0000000000003983. PubMed PMID:37235762 .
  2. Tinévez, C, Lehours, P, Ranc, AG, Belaroussi, Y, Velardo, F, Dubois, D et al.. Multicenter Retrospective Study of Vascular Infections and Endocarditis Caused by Campylobacter spp., France. Emerg Infect Dis. 2023;29 (3):484-492. doi: 10.3201/eid2903.221417. PubMed PMID:36823023 PubMed Central PMC9973684.
  3. Jousset, AB, Bernabeu, S, Emeraud, C, Bonnin, RA, Lomont, A, Zahar, JR et al.. Evaluation of ceftolozane-tazobactam susceptibility on a French nationwide collection of Enterobacterales. J Glob Antimicrob Resist. 2023;32 :78-84. doi: 10.1016/j.jgar.2023.01.003. PubMed PMID:36708769 .
  4. Debray, A, Callot, D, Hirt, D, Bille, E, Renolleau, S, Chouchana, L et al.. Correction to: Beta-lactam exposure and safety in intermittent or continuous infusion in critically ill children: an observational monocenter study. Eur J Pediatr. 2023;182 (3):975-976. doi: 10.1007/s00431-022-04762-8. PubMed PMID:36529772 .
  5. Debray, A, Callot, D, Hirt, D, Bille, E, Renolleau, S, Chouchana, L et al.. Beta-lactam exposure and safety in intermittent or continuous infusion in critically ill children: an observational monocenter study. Eur J Pediatr. 2023;182 (3):965-973. doi: 10.1007/s00431-022-04716-0. PubMed PMID:36422708 .
  6. Thy, M, Urien, S, Foissac, F, Bouazza, N, Gana, I, Bille, E et al.. Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy. Antimicrob Agents Chemother. 2022;66 (12):e0113522. doi: 10.1128/aac.01135-22. PubMed PMID:36342152 PubMed Central PMC9764994.
  7. Thy, M, Urien, S, Bouazza, N, Foissac, F, Gana, I, Bille, E et al.. Meropenem Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy. Clin Pharmacokinet. 2022;61 (11):1609-1621. doi: 10.1007/s40262-022-01179-2. PubMed PMID:36251162 .
  8. Pizzato, J, Tang, W, Bernabeu, S, Bonnin, RA, Bille, E, Farfour, E et al.. Discrimination of Escherichia coli, Shigella flexneri, and Shigella sonnei using lipid profiling by MALDI-TOF mass spectrometry paired with machine learning. Microbiologyopen. 2022;11 (4):e1313. doi: 10.1002/mbo3.1313. PubMed PMID:36004556 PubMed Central PMC9405496.
  9. de Cacqueray, N, Hirt, D, Zheng, Y, Bille, E, Leger, PL, Rambaud, J et al.. Cefepime population pharmacokinetics and dosing regimen optimization in critically ill children with different renal function. Clin Microbiol Infect. 2022;28 (10):1389.e1-1389.e7. doi: 10.1016/j.cmi.2022.05.007. PubMed PMID:35605841 .
  10. Farfour, E, Dortet, L, Guillard, T, Chatelain, N, Poisson, A, Mizrahi, A et al.. Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France. Pathogens. 2022;11 (3):. doi: 10.3390/pathogens11030356. PubMed PMID:35335681 PubMed Central PMC8949168.
  11. de Cacqueray, N, Boujaafar, S, Bille, E, Moulin, F, Gana, I, Benaboud, S et al.. Therapeutic Drug Monitoring of Antibiotics in Critically Ill Children: An Observational Study in a Pediatric Intensive Care Unit. Ther Drug Monit. 2022;44 (2):319-327. doi: 10.1097/FTD.0000000000000918. PubMed PMID:35292609 .
  12. Beauruelle, C, Plouzeau, C, Grillon, A, Isnard, C, Corvec, S, Degand, N et al.. Capnocytophaga zoonotic infections: a 10-year retrospective study (the French CANCAN study). Eur J Clin Microbiol Infect Dis. 2022;41 (4):581-588. doi: 10.1007/s10096-022-04402-x. PubMed PMID:35064380 .
  13. Lombes, A, Bonnin, RA, Laurent, F, Guet-Revillet, H, Bille, E, Cattoir, V et al.. High Prevalence of OXA-23 Carbapenemase-Producing Proteus mirabilis among Amoxicillin-Clavulanate-Resistant Isolates in France. Antimicrob Agents Chemother. 2022;66 (2):e0198321. doi: 10.1128/AAC.01983-21. PubMed PMID:34930033 PubMed Central PMC8846483.
  14. Tinévez, C, Velardo, F, Ranc, AG, Dubois, D, Pailhoriès, H, Codde, C et al.. Retrospective Multicentric Study on Campylobacter spp. Bacteremia in France: The Campylobacteremia Study. Clin Infect Dis. 2022;75 (4):702-709. doi: 10.1093/cid/ciab983. PubMed PMID:34849656 .
  15. Barnier, JP, Meyer, J, Kolappan, S, Bouzinba-Ségard, H, Gesbert, G, Jamet, A et al.. The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci U S A. 2021;118 (45):. doi: 10.1073/pnas.2109364118. PubMed PMID:34725157 PubMed Central PMC8609321.
  16. Runyo, F, Beaudoin, MC, Hammadi, B, Morgand, M, Driessen, M, Sellier, Y et al.. Procalcitonin use for the screening of bacterial infections in pregnant women in the emergency ward: A prospective study. J Infect. 2021;83 (3):e4-e5. doi: 10.1016/j.jinf.2021.07.005. PubMed PMID:34271061 .
  17. Medjebeur Hanna, R, Levy, M, Bille, E, Hennequin, C, Lesage, F, Naudin, J et al.. Assessment of the Effects of a High Amikacin Dose on Plasma Peak Concentration in Critically Ill Children. Paediatr Drugs. 2021;23 (4):395-401. doi: 10.1007/s40272-021-00456-0. PubMed PMID:34142330 .
  18. Farfour, E, Si Larbi, AG, Cattoir, V, Corvec, S, Guillard, T, Grillon, A et al.. Temocillin susceptibility among Enterobacterales strains recovered from blood culture in France. Diagn Microbiol Infect Dis. 2021;100 (3):115368. doi: 10.1016/j.diagmicrobio.2021.115368. PubMed PMID:33813355 .
  19. Lefèvre, CR, Pelletier, R, Le Monnier, A, Corvec, S, Bille, E, Potron, A et al.. Clinical relevance and antimicrobial susceptibility profile of the unknown human pathogen Corynebacterium aurimucosum. J Med Microbiol. 2021;70 (3):. doi: 10.1099/jmm.0.001334. PubMed PMID:33734955 .
  20. Cormontagne, D, Rigourd, V, Vidic, J, Rizzotto, F, Bille, E, Ramarao, N et al.. Bacillus cereus Induces Severe Infections in Preterm Neonates: Implication at the Hospital and Human Milk Bank Level. Toxins (Basel). 2021;13 (2):. doi: 10.3390/toxins13020123. PubMed PMID:33562185 PubMed Central PMC7915446.
  21. Poline, J, Postaire, M, Parize, P, Pilmis, B, Bille, E, Zahar, JR et al.. Stewardship program on carbapenem prescriptions in a tertiary hospital for adults and children in France: a cohort study. Eur J Clin Microbiol Infect Dis. 2021;40 (5):1039-1048. doi: 10.1007/s10096-020-04103-3. PubMed PMID:33389261 PubMed Central PMC7778866.
  22. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 PubMed Central PMC8106705.
  23. Decalonne, M, Dos Santos, S, Gimenes, R, Goube, F, Abadie, G, Aberrane, S et al.. Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units. Eur J Clin Microbiol Infect Dis. 2020;39 (11):2185-2194. doi: 10.1007/s10096-020-03925-5. PubMed PMID:32519215 PubMed Central PMC7561542.
  24. Pilmis, B, Alby-Laurent, F, Fasola, ML, Seegers, V, Guery, R, Guet-Revillet, H et al.. Pseudomonas aeruginosa bloodstream infections in children: a 9-year retrospective study. Eur J Pediatr. 2020;179 (8):1247-1254. doi: 10.1007/s00431-020-03598-4. PubMed PMID:32080759 .
  25. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Author Correction: Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):17535. doi: 10.1038/s41598-019-54253-4. PubMed PMID:31754179 PubMed Central PMC6872590.
Search PubMed