Bacterial systemic infections are a major public health issue worldwide. Even in Western countries where antibiotics and vaccines are readily available, bacterial infections remain a major cause of death. They occur both in the community context and in the context of medical care.
Our long term goal is a better understanding of the pathogenesis of bacterial systemic infections in order to identify new targets for prevention and treatment.
We focus on three pathogens, which are model organisms allowing us to address many facets of bacteria-host interactions: Neisseria meningitidisStaphylococcus aureus and Francisella tularensis.


posi-lab.fr

Our Lab is part of the Necker-Enfants Malades Institute (INEM) on the Necker campus that also hosts the Necker-Enfants Malades Hospital and the Imagine Institute. In addition to the amazing location we enjoy in the center of Paris near the Invalides and the Eiffel Tower, we benefit from the cutting edge technological platforms of the campus (cytometry, cell imaging, proteomic…).

One of the main features of our Institute is the close interaction between the research labs and the clinical departments of the Necker children hospital which is one of the leading pediatric hospitals in Europe. Our research projects are highly translational and dedicated to “bench to bedside” concept. Many researchers in our team have joint appointments in research labs and medical departments. The Necker-Enfants Malades Institute comprises today 19 research teams grouped in two departments. Our team belongs to the department of Immunology, Infectiology and Haematology (I2H) and has developed many national and international collaborations.

View of Paris from the windows of the lab

We are on Twitter

Delighted to be taking on the exciting challenge of Vice-President for International Affairs at Université de Paris – an opportunity for all of us, I hope! Pr Elizabeth Macintyre @NeckerInem @Univ_Paris @NeckerInem

We are very pleased to share our new story on Type IV #pili retraction and their role in vessels colonization in mice.
#Neisseria @NeckerInem @SandrineBOURDO5 @Mohamed_Elbehi @PLOSPathogens

#PLOSPathogens: https://dx.plos.org/10.1371/journal.ppat.1009299

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Impressive work ! 🤩@shaevitz and Zemer Gitai
@PNASNews

Competitive binding of independent extension and retraction motors explains the quantitative dynamics of type IV pili https://www.pnas.org/content/118/8/e2014926118

We are very pleased to share our new story on Type IV #pili retraction and their role in vessels colonization in mice.
#Neisseria @NeckerInem @SandrineBOURDO5 @Mohamed_Elbehi @PLOSPathogens

#PLOSPathogens: https://dx.plos.org/10.1371/journal.ppat.1009299

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