All Publications of the Pathogenesis of Systemic Infection Lab since 2016

2021

  1. Rytter, H, Jamet, A, Ziveri, J, Ramond, E, Coureuil, M, Lagouge-Roussey, P et al.. The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella. PLoS Pathog. 2021;17 (8):e1009326. doi: 10.1371/journal.ppat.1009326. PubMed PMID:34339477 .
  2. Ramond, E, Jamet, A, Ding, X, Euphrasie, D, Bouvier, C, Lallemant, L et al.. Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the Drosophila Larval Model. mBio. 2021;12 (3):e0027621. doi: 10.1128/mBio.00276-21. PubMed PMID:34126772 PubMed Central PMC8262968.
  3. Regnault, B, Evrard, B, Plu, I, Dacheux, L, Troadec, E, Cozette, P et al.. First case of lethal encephalitis in Western Europe due to European bat lyssavirus type 1. Clin Infect Dis. 2021; :. doi: 10.1093/cid/ciab443. PubMed PMID:33991184 .
  4. Barnier, JP, Euphrasie, D, Join-Lambert, O, Audry, M, Schonherr-Hellec, S, Schmitt, T et al.. Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model. PLoS Pathog. 2021;17 (2):e1009299. doi: 10.1371/journal.ppat.1009299. PubMed PMID:33592056 PubMed Central PMC7909687.
  5. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 PubMed Central PMC8106705.
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2020

  1. Skurnik, D, Rybak, A, Yang, DD, Pons, S, Guedj, R, Levy, C et al.. Unexpected lessons from the COVID-19 lockdowns in France: Low impact of school opening on common communicable pediatric airborne diseases. Clin Infect Dis. 2020; :. doi: 10.1093/cid/ciaa1899. PubMed PMID:33373441 PubMed Central PMC7799226.
  2. Rytter, H, Jamet, A, Coureuil, M, Charbit, A, Ramond, E. Which Current and Novel Diagnostic Avenues for Bacterial Respiratory Diseases?. Front Microbiol. 2020;11 :616971. doi: 10.3389/fmicb.2020.616971. PubMed PMID:33362754 PubMed Central PMC7758241.
  3. Quereda, JJ, Morel, C, Lopez-Montero, N, Ziveri, J, Rolland, S, Grenier, T et al.. A role for Taok2 in Listeria monocytogenes vacuolar escape. J Infect Dis. 2020; :. doi: 10.1093/infdis/jiaa367. PubMed PMID:32582947 .
  4. Marullo, S, Doly, S, Saha, K, Enslen, H, Scott, MGH, Coureuil, M et al.. Mechanical GPCR Activation by Traction Forces Exerted on Receptor N-Glycans. ACS Pharmacol Transl Sci. 2020;3 (2):171-178. doi: 10.1021/acsptsci.9b00106. PubMed PMID:32296760 PubMed Central PMC7155188.
  5. Dos Santos Souza, I, Maïssa, N, Ziveri, J, Morand, PC, Coureuil, M, Nassif, X et al.. Meningococcal disease: A paradigm of type-IV pilus dependent pathogenesis. Cell Microbiol. 2020;22 (4):e13185. doi: 10.1111/cmi.13185. PubMed PMID:32185901 .
  6. Sloan, SE, Szretter, KJ, Sundaresh, B, Narayan, KM, Smith, PF, Skurnik, D et al.. Clinical and virological responses to a broad-spectrum human monoclonal antibody in an influenza virus challenge study. Antiviral Res. 2020;184 :104763. doi: 10.1016/j.antiviral.2020.104763. PubMed PMID:32151645 .
  7. Le Guennec, L, Virion, Z, Bouzinba-Ségard, H, Robbe-Masselot, C, Léonard, R, Nassif, X et al.. Receptor recognition by meningococcal type IV pili relies on a specific complex N-glycan. Proc Natl Acad Sci U S A. 2020;117 (5):2606-2612. doi: 10.1073/pnas.1919567117. PubMed PMID:31964828 PubMed Central PMC7007569.
  8. Tan, X, Coureuil, M, Charbit, A, Jamet, A. Multitasking Actors of Staphylococcus aureus Metabolism and Virulence. Trends Microbiol. 2020;28 (1):6-9. doi: 10.1016/j.tim.2019.10.013. PubMed PMID:31753539 .
  9. Le Guennec, L, Coureuil, M, Nassif, X, Bourdoulous, S. Strategies used by bacterial pathogens to cross the blood-brain barrier. Cell Microbiol. 2020;22 (1):e13132. doi: 10.1111/cmi.13132. PubMed PMID:31658405 .
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2019

  1. Audry, M, Robbe-Masselot, C, Barnier, JP, Gachet, B, Saubaméa, B, Schmitt, A et al.. Airway Mucus Restricts Neisseria meningitidis Away from Nasopharyngeal Epithelial Cells and Protects the Mucosa from Inflammation. mSphere. 2019;4 (6):. doi: 10.1128/mSphere.00494-19. PubMed PMID:31801841 PubMed Central PMC6893211.
  2. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Author Correction: Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):17535. doi: 10.1038/s41598-019-54253-4. PubMed PMID:31754179 PubMed Central PMC6872590.
  3. Tan, X, Coureuil, M, Charbit, A, Jamet, A. Multitasking Actors of Staphylococcus aureus Metabolism and Virulence. Trends Microbiol. 2020;28 (1):6-9. doi: 10.1016/j.tim.2019.10.013. PubMed PMID:31753539 .
  4. Ramond, E, Jamet, A, Coureuil, M, Charbit, A. Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens. Front Immunol. 2019;10 :2461. doi: 10.3389/fimmu.2019.02461. PubMed PMID:31708919 PubMed Central PMC6819784.
  5. Le Guennec, L, Coureuil, M, Nassif, X, Bourdoulous, S. Strategies used by bacterial pathogens to cross the blood-brain barrier. Cell Microbiol. 2020;22 (1):e13132. doi: 10.1111/cmi.13132. PubMed PMID:31658405 .
  6. Virion, Z, Doly, S, Saha, K, Lambert, M, Guillonneau, F, Bied, C et al.. Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili. Nat Commun. 2019;10 (1):4752. doi: 10.1038/s41467-019-12685-6. PubMed PMID:31628314 PubMed Central PMC6800425.
  7. Ziveri, J, Chhuon, C, Jamet, A, Rytter, H, Prigent, G, Tros, F et al.. Critical Role of a Sheath Phosphorylation Site On the Assembly and Function of an Atypical Type VI Secretion System. Mol Cell Proteomics. 2019;18 (12):2418-2432. doi: 10.1074/mcp.RA119.001532. PubMed PMID:31578219 PubMed Central PMC6885697.
  8. Tan, X, Ramond, E, Jamet, A, Barnier, JP, Decaux-Tramoni, B, Dupuis, M et al.. Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection. J Infect Dis. 2019;220 (12):1967-1976. doi: 10.1093/infdis/jiz404. PubMed PMID:31420648 .
  9. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  10. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):6516. doi: 10.1038/s41598-019-42751-4. PubMed PMID:31019198 PubMed Central PMC6482305.
  11. Vidal, C, Moulin, F, Nassif, X, Galmiche, L, Borgel, D, Charbit, A et al.. Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report. BMC Infect Dis. 2019;19 (1):302. doi: 10.1186/s12879-019-3933-3. PubMed PMID:30943907 PubMed Central PMC6446405.
  12. Virion, Z, Marullo, S, Coureuil, M. Methods to Study the Roles of β-Arrestins in Meningococcal Signaling. Methods Mol Biol. 2019;1957 :325-334. doi: 10.1007/978-1-4939-9158-7_20. PubMed PMID:30919363 .
  13. Denis, K, Le Bris, M, Le Guennec, L, Barnier, JP, Faure, C, Gouge, A et al.. Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease. Nat Microbiol. 2019;4 (6):972-984. doi: 10.1038/s41564-019-0395-8. PubMed PMID:30911127 .
  14. Aschard, H, Laville, V, Tchetgen, ET, Knights, D, Imhann, F, Seksik, P et al.. Genetic effects on the commensal microbiota in inflammatory bowel disease patients. PLoS Genet. 2019;15 (3):e1008018. doi: 10.1371/journal.pgen.1008018. PubMed PMID:30849075 PubMed Central PMC6426259.
  15. Tan, X, Coureuil, M, Ramond, E, Euphrasie, D, Dupuis, M, Tros, F et al.. Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence. Clin Infect Dis. 2019;69 (11):1937-1945. doi: 10.1093/cid/ciz106. PubMed PMID:30753350 .
  16. Lécuyer, H, Nassif, X, Coureuil, M. [Meningococcus purpura fulminans, a partially solved mystery]. Med Sci (Paris). 2018;34 (12):1038-1041. doi: 10.1051/medsci/2018288. PubMed PMID:30623761 .
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2018

  1. Lécuyer, H, Nassif, X, Coureuil, M. [Meningococcus purpura fulminans, a partially solved mystery]. Med Sci (Paris). 2018;34 (12):1038-1041. doi: 10.1051/medsci/2018288. PubMed PMID:30623761 .
  2. Le Gallou, S, Zhou, Z, Thai, LH, Fritzen, R, de Los Aires, AV, Mégret, J et al.. A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses. J Exp Med. 2018;215 (8):2035-2053. doi: 10.1084/jem.20180977. PubMed PMID:29959173 PubMed Central PMC6080908.
  3. Lécuyer, H, Virion, Z, Barnier, JP, Matczak, S, Bourdoulous, S, Bianchini, E et al.. An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. PLoS Pathog. 2018;14 (4):e1006981. doi: 10.1371/journal.ppat.1006981. PubMed PMID:29630665 PubMed Central PMC5908201.
  4. Brauge, T, Faille, C, Sadovskaya, I, Charbit, A, Benezech, T, Shen, Y et al.. The absence of N-acetylglucosamine in wall teichoic acids of Listeria monocytogenes modifies biofilm architecture and tolerance to rinsing and cleaning procedures. PLoS One. 2018;13 (1):e0190879. doi: 10.1371/journal.pone.0190879. PubMed PMID:29320565 PubMed Central PMC5761963.
  5. Jamet, A, Charbit, A, Nassif, X. Antibacterial Toxins: Gram-Positive Bacteria Strike Back!. Trends Microbiol. 2018;26 (2):89-91. doi: 10.1016/j.tim.2017.11.003. PubMed PMID:29174101 .
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2017

  1. Jamet, A, Charbit, A, Nassif, X. Antibacterial Toxins: Gram-Positive Bacteria Strike Back!. Trends Microbiol. 2018;26 (2):89-91. doi: 10.1016/j.tim.2017.11.003. PubMed PMID:29174101 .
  2. Capel, E, Barnier, JP, Zomer, AL, Bole-Feysot, C, Nussbaumer, T, Jamet, A et al.. Peripheral blood vessels are a niche for blood-borne meningococci. Virulence. 2017;8 (8):1808-1819. doi: 10.1080/21505594.2017.1391446. PubMed PMID:29099305 PubMed Central PMC5810509.
  3. Ouldali, N, Bellêttre, X, Milcent, K, Guedj, R, de Pontual, L, Cojocaru, B et al.. Impact of Implementing National Guidelines on Antibiotic Prescriptions for Acute Respiratory Tract Infections in Pediatric Emergency Departments: An Interrupted Time Series Analysis. Clin Infect Dis. 2017;65 (9):1469-1476. doi: 10.1093/cid/cix590. PubMed PMID:29048511 .
  4. Aschard, H, Guillemot, V, Vilhjalmsson, B, Patel, CJ, Skurnik, D, Ye, CJ et al.. Covariate selection for association screening in multiphenotype genetic studies. Nat Genet. 2017;49 (12):1789-1795. doi: 10.1038/ng.3975. PubMed PMID:29038595 PubMed Central PMC5797835.
  5. Ziveri, J, Tros, F, Guerrera, IC, Chhuon, C, Audry, M, Dupuis, M et al.. The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella. Nat Commun. 2017;8 (1):853. doi: 10.1038/s41467-017-00889-7. PubMed PMID:29021545 PubMed Central PMC5636795.
  6. Wang, F, Coureuil, M, Osinski, T, Orlova, A, Altindal, T, Gesbert, G et al.. Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution. Structure. 2017;25 (9):1423-1435.e4. doi: 10.1016/j.str.2017.07.016. PubMed PMID:28877506 PubMed Central PMC8189185.
  7. Jamet, A, Touchon, M, Ribeiro-Gonçalves, B, Carriço, JA, Charbit, A, Nassif, X et al.. A widespread family of polymorphic toxins encoded by temperate phages. BMC Biol. 2017;15 (1):75. doi: 10.1186/s12915-017-0415-1. PubMed PMID:28851366 PubMed Central PMC5576092.
  8. Ghenassia, A, Gross, DA, Lorain, S, Tros, F, Urbain, D, Benkhelifa-Ziyyat, S et al.. Intradermal Immunization with rAAV1 Vector Induces Robust Memory CD8+ T Cell Responses Independently of Transgene Expression in DCs. Mol Ther. 2017;25 (10):2309-2322. doi: 10.1016/j.ymthe.2017.06.019. PubMed PMID:28720467 PubMed Central PMC5628776.
  9. Bille, E, Meyer, J, Jamet, A, Euphrasie, D, Barnier, JP, Brissac, T et al.. A virulence-associated filamentous bacteriophage of Neisseria meningitidis increases host-cell colonisation. PLoS Pathog. 2017;13 (7):e1006495. doi: 10.1371/journal.ppat.1006495. PubMed PMID:28704569 PubMed Central PMC5526601.
  10. Maïssa, N, Covarelli, V, Janel, S, Durel, B, Simpson, N, Bernard, SC et al.. Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4. Nat Commun. 2017;8 :15764. doi: 10.1038/ncomms15764. PubMed PMID:28569760 PubMed Central PMC5461506.
  11. Guet-Revillet, H, Jais, JP, Ungeheuer, MN, Coignard-Biehler, H, Duchatelet, S, Delage, M et al.. The Microbiological Landscape of Anaerobic Infections in Hidradenitis Suppurativa: A Prospective Metagenomic Study. Clin Infect Dis. 2017;65 (2):282-291. doi: 10.1093/cid/cix285. PubMed PMID:28379372 .
  12. Barel, M, Charbit, A. Role of Glycosylation/Deglycolysation Processes in Francisella tularensis Pathogenesis. Front Cell Infect Microbiol. 2017;7 :71. doi: 10.3389/fcimb.2017.00071. PubMed PMID:28377902 PubMed Central PMC5359314.
  13. Roux, D, Weatherholt, M, Clark, B, Gadjeva, M, Renaud, D, Scott, D et al.. Immune Recognition of the Epidemic Cystic Fibrosis Pathogen Burkholderia dolosa. Infect Immun. 2017;85 (6):. doi: 10.1128/IAI.00765-16. PubMed PMID:28348057 PubMed Central PMC5442610.
  14. Lécuyer, H, Borgel, D, Nassif, X, Coureuil, M. Pathogenesis of meningococcal purpura fulminans. Pathog Dis. 2017;75 (3):. doi: 10.1093/femspd/ftx027. PubMed PMID:28334263 .
  15. Coureuil, M, Lécuyer, H, Bourdoulous, S, Nassif, X. A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers. Nat Rev Microbiol. 2017;15 (3):149-159. doi: 10.1038/nrmicro.2016.178. PubMed PMID:28090076 .
  16. Sokol, H, Leducq, V, Aschard, H, Pham, HP, Jegou, S, Landman, C et al.. Fungal microbiota dysbiosis in IBD. Gut. 2017;66 (6):1039-1048. doi: 10.1136/gutjnl-2015-310746. PubMed PMID:26843508 PubMed Central PMC5532459.
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2016

  1. Kolappan, S, Coureuil, M, Yu, X, Nassif, X, Egelman, EH, Craig, L et al.. Structure of the Neisseria meningitidis Type IV pilus. Nat Commun. 2016;7 :13015. doi: 10.1038/ncomms13015. PubMed PMID:27698424 PubMed Central PMC5059446.
  2. Rigard, M, Bröms, JE, Mosnier, A, Hologne, M, Martin, A, Lindgren, L et al.. Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence. PLoS Pathog. 2016;12 (9):e1005821. doi: 10.1371/journal.ppat.1005821. PubMed PMID:27602570 PubMed Central PMC5014421.
  3. Capel, E, Zomer, AL, Nussbaumer, T, Bole, C, Izac, B, Frapy, E et al.. Comprehensive Identification of Meningococcal Genes and Small Noncoding RNAs Required for Host Cell Colonization. mBio. 2016;7 (4):. doi: 10.1128/mBio.01173-16. PubMed PMID:27486197 PubMed Central PMC4981724.
  4. Bergounioux, J, Coureuil, M, Belli, E, Ly, M, Cambillau, M, Goudin, N et al.. Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during Meningococcemia. Infect Immun. 2016;84 (10):3017-23. doi: 10.1128/IAI.00420-16. PubMed PMID:27481255 PubMed Central PMC5038069.
  5. Pizarro-Cerdá, J, Charbit, A, Enninga, J, Lafont, F, Cossart, P. Manipulation of host membranes by the bacterial pathogens Listeria, Francisella, Shigella and Yersinia. Semin Cell Dev Biol. 2016;60 :155-167. doi: 10.1016/j.semcdb.2016.07.019. PubMed PMID:27448494 PubMed Central PMC7082150.
  6. Guillard, T, Pons, S, Roux, D, Pier, GB, Skurnik, D. Antibiotic resistance and virulence: Understanding the link and its consequences for prophylaxis and therapy. Bioessays. 2016;38 (7):682-93. doi: 10.1002/bies.201500180. PubMed PMID:27248008 .
  7. Barel, M, Harduin-Lepers, A, Portier, L, Slomianny, MC, Charbit, A. Host glycosylation pathways and the unfolded protein response contribute to the infection by Francisella. Cell Microbiol. 2016;18 (12):1763-1781. doi: 10.1111/cmi.12614. PubMed PMID:27185209 .
  8. Sokol, H, Leducq, V, Aschard, H, Pham, HP, Jegou, S, Landman, C et al.. Fungal microbiota dysbiosis in IBD. Gut. 2017;66 (6):1039-1048. doi: 10.1136/gutjnl-2015-310746. PubMed PMID:26843508 PubMed Central PMC5532459.
  9. Roux, D, Pons, S, Guillard, T, Ricard, JD, Pier, GB, Skurnik, D et al.. Impact of Drug Resistance on Virulence and Fitness of Bacterial Pathogens. Crit Care Med. 2016;44 (1):e50. doi: 10.1097/CCM.0000000000001330. PubMed PMID:26672941 .
  10. Skurnik, D, Clermont, O, Guillard, T, Launay, A, Danilchanka, O, Pons, S et al.. Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans. Mol Biol Evol. 2016;33 (4):898-914. doi: 10.1093/molbev/msv280. PubMed PMID:26613786 PubMed Central PMC5013867.
  11. Meyer, J, Brissac, T, Frapy, E, Omer, H, Euphrasie, D, Bonavita, A et al.. Characterization of MDAΦ, a temperate filamentous bacteriophage of Neisseria meningitidis. Microbiology (Reading). 2016;162 (2):268-282. doi: 10.1099/mic.0.000215. PubMed PMID:26602366 .
  12. Join-Lambert, O, Coignard-Biehler, H, Jais, JP, Delage, M, Guet-Revillet, H, Poirée, S et al.. Efficacy of ertapenem in severe hidradenitis suppurativa: a pilot study in a cohort of 30 consecutive patients. J Antimicrob Chemother. 2016;71 (2):513-20. doi: 10.1093/jac/dkv361. PubMed PMID:26565016 .
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