Anne Jamet

Anne Jamet is a medical doctor and clinical microbiologist. She is an associate professor (MCU-PH) in the Unit of « Pathogenesis of Systemic Infections » (U1151-E7, INEM, Paris) and an academic practitioner in the Microbiology Laboratory of the Necker Children’s Hospital. Anne Jamet is in charge of the next-generation sequencing of bacterial genomes at the Necker Hospital since 2013. She is involved in the setting up of the “clinical metagenomic” plateform for microbiological diagnostic at the Necker Hospital allowing direct sequencing of clinical samples in collaboration with the Pathogen Discovery Laboratory (led by Dr Marc Eloit at the Pasteur Institute, Paris).

Besides her clinical activities in the Necker Hospital, she pursues fundamental research activities in the U1151 team 7. After having spent several years studying meningococcus biology and the role of polymorphic toxins in colonization, she now primarily focuses on the adaptation of S. aureus during chronic infections. In tight collaboration with the Microbiology Laboratory and the departments of paediatric pneumology and dermatology of the Necker Hospital, the S. aureus research team leverages 2 main disease models of chronic infections: the cystic fibrosis and epidermolysis bullosa models.

Anne Jamet

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Last News of the Lab

The pentose phosphate pathway in pathogenic Francisella

Le 03/08/2021 .The pentose phosphate pathway constitutes a major metabolic hub in pathogenic FrancisellaHéloise Rytter et al PLOS Pathogens 2021. Metabolic pathways are now considered as intrinsic virulence attributes of pathogenic bacteria and thus represent potential targets for antibacterial strategies. Here we focused on the role of the pentose phosphate pathway (PPP) and its connections ...
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Grant ANR JCJC – Anne Jamet

Le 03/08/2021 .Anne Jamet was granted ANR JCJC for her project on S. aureus and chronic lung infections in cystic fibrosis Impact of S. aureus on the outcome of chronic lung infections in cystic fibrosis Cystic fibrosis (CF) is the most frequent severe recessive disorder in European populations. In France, Staphylococcus aureus (Sa) dominates the ...
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Congratulation to Audrey LAURENT, Clémence MOUVILLE and Xiali FU

Le 02/08/2021 .Audrey LAURENT and Clémence MOUVILLE have been awarded a PhD Track Grant from BioSPC. Xiali FU has been awarded a PhD Track Grant from China Scholarship Council. We are all very proud and very excited about the science to come. Audrey will work on Neisseria meningitidis and host-cell membrane. Clémence will work on ...
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Last 25 Publications

  1. Rytter, H, Jamet, A, Ziveri, J, Ramond, E, Coureuil, M, Lagouge-Roussey, P et al.. The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella. PLoS Pathog. 2021;17 (8):e1009326. doi: 10.1371/journal.ppat.1009326. PubMed PMID:34339477 PubMed Central PMC8360588.
  2. Ramond, E, Jamet, A, Ding, X, Euphrasie, D, Bouvier, C, Lallemant, L et al.. Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the Drosophila Larval Model. mBio. 2021;12 (3):e0027621. doi: 10.1128/mBio.00276-21. PubMed PMID:34126772 PubMed Central PMC8262968.
  3. Regnault, B, Evrard, B, Plu, I, Dacheux, L, Troadec, E, Cozette, P et al.. First case of lethal encephalitis in Western Europe due to European bat lyssavirus type 1. Clin Infect Dis. 2021; :. doi: 10.1093/cid/ciab443. PubMed PMID:33991184 .
  4. Rytter, H, Jamet, A, Coureuil, M, Charbit, A, Ramond, E. Which Current and Novel Diagnostic Avenues for Bacterial Respiratory Diseases?. Front Microbiol. 2020;11 :616971. doi: 10.3389/fmicb.2020.616971. PubMed PMID:33362754 PubMed Central PMC7758241.
  5. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 PubMed Central PMC8106705.
  6. Tan, X, Coureuil, M, Charbit, A, Jamet, A. Multitasking Actors of Staphylococcus aureus Metabolism and Virulence. Trends Microbiol. 2020;28 (1):6-9. doi: 10.1016/j.tim.2019.10.013. PubMed PMID:31753539 .
  7. Ramond, E, Jamet, A, Coureuil, M, Charbit, A. Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens. Front Immunol. 2019;10 :2461. doi: 10.3389/fimmu.2019.02461. PubMed PMID:31708919 PubMed Central PMC6819784.
  8. Ziveri, J, Chhuon, C, Jamet, A, Rytter, H, Prigent, G, Tros, F et al.. Critical Role of a Sheath Phosphorylation Site On the Assembly and Function of an Atypical Type VI Secretion System. Mol Cell Proteomics. 2019;18 (12):2418-2432. doi: 10.1074/mcp.RA119.001532. PubMed PMID:31578219 PubMed Central PMC6885697.
  9. Tan, X, Ramond, E, Jamet, A, Barnier, JP, Decaux-Tramoni, B, Dupuis, M et al.. Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection. J Infect Dis. 2019;220 (12):1967-1976. doi: 10.1093/infdis/jiz404. PubMed PMID:31420648 .
  10. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  11. Vidal, C, Moulin, F, Nassif, X, Galmiche, L, Borgel, D, Charbit, A et al.. Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report. BMC Infect Dis. 2019;19 (1):302. doi: 10.1186/s12879-019-3933-3. PubMed PMID:30943907 PubMed Central PMC6446405.
  12. Denis, K, Le Bris, M, Le Guennec, L, Barnier, JP, Faure, C, Gouge, A et al.. Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease. Nat Microbiol. 2019;4 (6):972-984. doi: 10.1038/s41564-019-0395-8. PubMed PMID:30911127 .
  13. Tan, X, Coureuil, M, Ramond, E, Euphrasie, D, Dupuis, M, Tros, F et al.. Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence. Clin Infect Dis. 2019;69 (11):1937-1945. doi: 10.1093/cid/ciz106. PubMed PMID:30753350 .
  14. Jamet, A, Charbit, A, Nassif, X. Antibacterial Toxins: Gram-Positive Bacteria Strike Back!. Trends Microbiol. 2018;26 (2):89-91. doi: 10.1016/j.tim.2017.11.003. PubMed PMID:29174101 .
  15. Capel, E, Barnier, JP, Zomer, AL, Bole-Feysot, C, Nussbaumer, T, Jamet, A et al.. Peripheral blood vessels are a niche for blood-borne meningococci. Virulence. 2017;8 (8):1808-1819. doi: 10.1080/21505594.2017.1391446. PubMed PMID:29099305 PubMed Central PMC5810509.
  16. Jamet, A, Touchon, M, Ribeiro-Gonçalves, B, Carriço, JA, Charbit, A, Nassif, X et al.. A widespread family of polymorphic toxins encoded by temperate phages. BMC Biol. 2017;15 (1):75. doi: 10.1186/s12915-017-0415-1. PubMed PMID:28851366 PubMed Central PMC5576092.
  17. Bille, E, Meyer, J, Jamet, A, Euphrasie, D, Barnier, JP, Brissac, T et al.. A virulence-associated filamentous bacteriophage of Neisseria meningitidis increases host-cell colonisation. PLoS Pathog. 2017;13 (7):e1006495. doi: 10.1371/journal.ppat.1006495. PubMed PMID:28704569 PubMed Central PMC5526601.
  18. Capel, E, Zomer, AL, Nussbaumer, T, Bole, C, Izac, B, Frapy, E et al.. Comprehensive Identification of Meningococcal Genes and Small Noncoding RNAs Required for Host Cell Colonization. mBio. 2016;7 (4):. doi: 10.1128/mBio.01173-16. PubMed PMID:27486197 PubMed Central PMC4981724.
  19. Jamet, A, Nassif, X. Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species. Microb Cell. 2015;2 (3):88-90. doi: 10.15698/mic2015.03.194. PubMed PMID:28357281 PubMed Central PMC5349182.
  20. Jamet, A, Jousset, AB, Euphrasie, D, Mukorako, P, Boucharlat, A, Ducousso, A et al.. A new family of secreted toxins in pathogenic Neisseria species. PLoS Pathog. 2015;11 (1):e1004592. doi: 10.1371/journal.ppat.1004592. PubMed PMID:25569427 PubMed Central PMC4287609.
  21. Join-Lambert, O, Lecuyer, H, Miller, F, Lelievre, L, Jamet, A, Furio, L et al.. Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans. J Infect Dis. 2013;208 (10):1590-7. doi: 10.1093/infdis/jit301. PubMed PMID:23840047 .
  22. Jamet, A, Euphrasie, D, Martin, P, Nassif, X. Identification of genes involved in Neisseria meningitidis colonization. Infect Immun. 2013;81 (9):3375-81. doi: 10.1128/IAI.00421-13. PubMed PMID:23817612 PubMed Central PMC3754196.
  23. Jamet, A, Frapy, E, Schneider, D, Nassif, X, Martin, P. A cell-contact-regulated operon is involved in genetic variability in Neisseria meningitidis. Res Microbiol. 2012;163 (3):192-9. doi: 10.1016/j.resmic.2011.12.005. PubMed PMID:22212726 .
  24. Delamarre, D, Lillo-Le Louët, A, Guillot, L, Jamet, A, Sadou, E, Ouazine, T et al.. Documentation in pharmacovigilance: using an ontology to extend and normalize Pubmed queries. Stud Health Technol Inform. 2010;160 (Pt 1):518-22. . PubMed PMID:20841741 .
  25. Jamet, A, Rousseau, C, Monfort, JB, Nassif, X, Martin, P. Identification of a novel transcriptional regulator involved in pilC1 regulation in Neisseria meningitidis. FEMS Microbiol Lett. 2010;304 (2):140-7. doi: 10.1111/j.1574-6968.2009.01894.x. PubMed PMID:20377643 .
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