Anne Jamet

Anne Jamet is group leader in the team.
AJ is a medical doctor and clinical microbiologist. She is an associate professor (MCU-PH) in the Unit of « Pathogenesis of Systemic Infections » (U1151-E7, INEM, Paris) and an academic practitioner in the Microbiology Laboratory of the Necker Children’s Hospital. Anne Jamet is in charge of the next-generation sequencing of bacterial genomes at the Necker Hospital since 2013. She is involved in the setting up of the “clinical metagenomic” plateform for microbiological diagnostic at the Necker Hospital allowing direct sequencing of clinical samples in collaboration with the Pathogen Discovery Laboratory (led by Dr Marc Eloit at the Pasteur Institute, Paris).

Besides her clinical activities in the Necker Hospital, she pursues fundamental research activities in the U1151 team 7. After having spent several years studying meningococcus biology and the role of polymorphic toxins in colonization, she now primarily focuses on the adaptation of S. aureus during chronic infections. In tight collaboration with the Microbiology Laboratory and the departments of paediatric pneumology and dermatology of the Necker Hospital, the S. aureus research team leverages 2 main disease models of chronic infections: the cystic fibrosis and epidermolysis bullosa models.

Anne Jamet
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Last News of the Lab

Performance of clinical metagenomics in France: a prospective observational study

11/12/2023Performance of clinical metagenomics in France: a prospective observational studyJacques Fourgeaud et al. Lancet Microbe 2023 Background Metagenomic next-generation sequencing (mNGS) allows untargeted identification of a broad range of pathogens, including rare or novel microorganisms. Despite the recognition of mNGS as a valuable diagnostic tool for infections, the most relevant indications for this innovative strategy ...

Airway environment promote Staphylococcus aureus chronic lifestyle

11/12/2023Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyleXiongqi Ding et al. Nat Commun 2023 Staphylococcus aureus is a predominant cause of chronic lung infections. While the airway environment is rich in highly sialylated mucins, the interaction of S. aureus with sialic acid is poorly characterized. Using S. aureus USA300 as well as clinical isolates, we ...

Congratulation to Morgane Wuckelt and Elif UYAR

24/07/2023 .Morgane Wuckelt and Elif Uyar have been awarded a PhD Track Grant from BioSPC. We are all very proud and very excited about the science to come. Morgane will work on Neisseria meningitidis and Type IV Pili. Elif will work on Staphylococcus aureus adaptation to chronic infections ...

Last 25 Publications

  1. Bardin, E, Dietrich, C, Attailia, M, Ferroni, A, Jamet, A, Lezmi, G et al.. Restored Cytokine-Producing Capacities of Mucosal-associated Invariant T Cells in Pediatric Cystic Fibrosis Patients Treated with Elexacaftor/Tezacaftor/Ivacaftor. Am J Respir Crit Care Med. 2024;210 (2):243-245. doi: 10.1164/rccm.202401-0201LE. PubMed PMID:38760016 .
  2. Rytter, H, Roger, K, Chhuon, C, Ding, X, Coureuil, M, Jamet, A et al.. Dual proteomics of infected macrophages reveal bacterial and host players involved in the Francisella intracellular life cycle and cell to cell dissemination by merocytophagy. Sci Rep. 2024;14 (1):7797. doi: 10.1038/s41598-024-58261-x. PubMed PMID:38565565 PubMed Central PMC10987565.
  3. Ding, X, Robbe-Masselot, C, Fu, X, Léonard, R, Marsac, B, Dauriat, CJG et al.. Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle. Nat Commun. 2023;14 (1):8135. doi: 10.1038/s41467-023-43863-2. PubMed PMID:38065959 PubMed Central PMC10709412.
  4. Fourgeaud, J, Regnault, B, Ok, V, Da Rocha, N, Sitterlé, É, Mekouar, M et al.. Performance of clinical metagenomics in France: a prospective observational study. Lancet Microbe. 2024;5 (1):e52-e61. doi: 10.1016/S2666-5247(23)00244-6. PubMed PMID:38048804 .
  5. Fourgeaud, J, Lecuit, MM, Pérot, P, Bruneau, J, Regnault, B, Da Rocha, N et al.. Chronic Aichi Virus Infection As a Cause of Long-Lasting Multiorgan Involvement in Patients With Primary Immune Deficiencies. Clin Infect Dis. 2023;77 (4):620-628. doi: 10.1093/cid/ciad237. PubMed PMID:37078608 .
  6. Avramescu, M, Isnard, P, Temmam, S, Chevalier, A, Bastard, P, Attia, M et al.. Acute tubulointerstitial nephritis with or without uveitis: a novel form of post-acute COVID-19 syndrome in children. Kidney Int. 2023;103 (6):1193-1198. doi: 10.1016/j.kint.2023.02.028. PubMed PMID:36918081 PubMed Central PMC10008186.
  7. Ding, X, Fu, X, Euphrasie, D, Ferroni, A, Sermet-Gaudelus, I, Charbit, A et al.. Genomic analysis of Staphylococcus aureus sequential isolates from lungs of patients with cystic fibrosis. Microbes Infect. 2023;25 (6):105124. doi: 10.1016/j.micinf.2023.105124. PubMed PMID:36871931 .
  8. Meyer, S, Puéchal, X, Quesne, G, Marques, I, Jamet, A, Ferroni, A et al.. Contribution of PCR to Differential Diagnosis between Patients with Whipple Disease and Tropheryma whipplei Carriers. J Clin Microbiol. 2023;61 (2):e0145722. doi: 10.1128/jcm.01457-22. PubMed PMID:36656022 PubMed Central PMC9945495.
  9. Riller, Q, Fourgeaud, J, Bruneau, J, De Ravin, SS, Smith, G, Fusaro, M et al.. Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients. J Allergy Clin Immunol. 2023;151 (6):1634-1645. doi: 10.1016/j.jaci.2022.12.822. PubMed PMID:36638922 PubMed Central PMC10336473.
  10. Ramond, E, Lepissier, A, Ding, X, Bouvier, C, Tan, X, Euphrasie, D et al.. Lung-Adapted Staphylococcus aureus Isolates With Dysfunctional Agr System Trigger a Proinflammatory Response. J Infect Dis. 2022;226 (7):1276-1285. doi: 10.1093/infdis/jiac191. PubMed PMID:35524969 .
  11. Barnier, JP, Meyer, J, Kolappan, S, Bouzinba-Ségard, H, Gesbert, G, Jamet, A et al.. The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci U S A. 2021;118 (45):. doi: 10.1073/pnas.2109364118. PubMed PMID:34725157 PubMed Central PMC8609321.
  12. Rytter, H, Jamet, A, Ziveri, J, Ramond, E, Coureuil, M, Lagouge-Roussey, P et al.. The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella. PLoS Pathog. 2021;17 (8):e1009326. doi: 10.1371/journal.ppat.1009326. PubMed PMID:34339477 PubMed Central PMC8360588.
  13. Ramond, E, Jamet, A, Ding, X, Euphrasie, D, Bouvier, C, Lallemant, L et al.. Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the Drosophila Larval Model. mBio. 2021;12 (3):e0027621. doi: 10.1128/mBio.00276-21. PubMed PMID:34126772 PubMed Central PMC8262968.
  14. Regnault, B, Evrard, B, Plu, I, Dacheux, L, Troadec, E, Cozette, P et al.. First Case of Lethal Encephalitis in Western Europe Due to European Bat Lyssavirus Type 1. Clin Infect Dis. 2022;74 (3):461-466. doi: 10.1093/cid/ciab443. PubMed PMID:33991184 .
  15. Rytter, H, Jamet, A, Coureuil, M, Charbit, A, Ramond, E. Which Current and Novel Diagnostic Avenues for Bacterial Respiratory Diseases?. Front Microbiol. 2020;11 :616971. doi: 10.3389/fmicb.2020.616971. PubMed PMID:33362754 PubMed Central PMC7758241.
  16. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 PubMed Central PMC8106705.
  17. Tan, X, Coureuil, M, Charbit, A, Jamet, A. Multitasking Actors of Staphylococcus aureus Metabolism and Virulence. Trends Microbiol. 2020;28 (1):6-9. doi: 10.1016/j.tim.2019.10.013. PubMed PMID:31753539 .
  18. Ramond, E, Jamet, A, Coureuil, M, Charbit, A. Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens. Front Immunol. 2019;10 :2461. doi: 10.3389/fimmu.2019.02461. PubMed PMID:31708919 PubMed Central PMC6819784.
  19. Ziveri, J, Chhuon, C, Jamet, A, Rytter, H, Prigent, G, Tros, F et al.. Critical Role of a Sheath Phosphorylation Site On the Assembly and Function of an Atypical Type VI Secretion System. Mol Cell Proteomics. 2019;18 (12):2418-2432. doi: 10.1074/mcp.RA119.001532. PubMed PMID:31578219 PubMed Central PMC6885697.
  20. Tan, X, Ramond, E, Jamet, A, Barnier, JP, Decaux-Tramoni, B, Dupuis, M et al.. Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection. J Infect Dis. 2019;220 (12):1967-1976. doi: 10.1093/infdis/jiz404. PubMed PMID:31420648 .
  21. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  22. Vidal, C, Moulin, F, Nassif, X, Galmiche, L, Borgel, D, Charbit, A et al.. Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report. BMC Infect Dis. 2019;19 (1):302. doi: 10.1186/s12879-019-3933-3. PubMed PMID:30943907 PubMed Central PMC6446405.
  23. Denis, K, Le Bris, M, Le Guennec, L, Barnier, JP, Faure, C, Gouge, A et al.. Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease. Nat Microbiol. 2019;4 (6):972-984. doi: 10.1038/s41564-019-0395-8. PubMed PMID:30911127 .
  24. Tan, X, Coureuil, M, Ramond, E, Euphrasie, D, Dupuis, M, Tros, F et al.. Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence. Clin Infect Dis. 2019;69 (11):1937-1945. doi: 10.1093/cid/ciz106. PubMed PMID:30753350 .
  25. Jamet, A, Charbit, A, Nassif, X. Antibacterial Toxins: Gram-Positive Bacteria Strike Back!. Trends Microbiol. 2018;26 (2):89-91. doi: 10.1016/j.tim.2017.11.003. PubMed PMID:29174101 .
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