Anne Jamet

Anne Jamet is group leader in the team.
AJ is a medical doctor and clinical microbiologist. She is an associate professor (MCU-PH) in the Unit of « Pathogenesis of Systemic Infections » (U1151-E7, INEM, Paris) and an academic practitioner in the Microbiology Laboratory of the Necker Children’s Hospital. Anne Jamet is in charge of the next-generation sequencing of bacterial genomes at the Necker Hospital since 2013. She is involved in the setting up of the “clinical metagenomic” plateform for microbiological diagnostic at the Necker Hospital allowing direct sequencing of clinical samples in collaboration with the Pathogen Discovery Laboratory (led by Dr Marc Eloit at the Pasteur Institute, Paris).

Besides her clinical activities in the Necker Hospital, she pursues fundamental research activities in the U1151 team 7. After having spent several years studying meningococcus biology and the role of polymorphic toxins in colonization, she now primarily focuses on the adaptation of S. aureus during chronic infections. In tight collaboration with the Microbiology Laboratory and the departments of paediatric pneumology and dermatology of the Necker Hospital, the S. aureus research team leverages 2 main disease models of chronic infections: the cystic fibrosis and epidermolysis bullosa models.

Anne Jamet

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Our new work : Implantation of engineered human microvasculature to study human infectious diseases in mouse models, is finally out 😀
@iScience_CP @NeckerInem @univ_paris_cite @INSB_CNRS @cdf1530
Great collaboration with Laurent Muller

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Last News of the Lab

Genomic analysis of S. aureus sequential isolates

27/03/2023 . Genomic analysis of Staphylococcus aureus sequential isolates from lungs of patients with cystic fibrosisDing et al Microbes and Infection 2023 Staphylococcus aureus is the predominant pathogen in children with cystic fibrosis (CF) in France and, around 80 % of them harbored S. aureus in their lungs. This study investigated virulence and antimicrobial resistance-associated ...
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Grant ANR JCJC – Anne Jamet

03/09/2022 .Anne Jamet was granted ANR PRC for her project on S. aureus, skin microbiota and host immune responses Deciphering how the interplay between dysbiosis and MAIT cells impacts skin repair The primary objective of the IMMUNESTA project is to better understand the crosstalk between skin microbiota and host immune responses in wound repair, with ...
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Lung-Adapted Staphylococcus aureus Trigger a Proinflammatory Response

07/05/2022 . Lung-Adapted Staphylococcus aureus Isolates With Dysfunctional Agr System Trigger a Proinflammatory ResponseElodie Ramond et al The Journal of Infectious Diseases 2022 BackgroundStaphylococcus aureus dominates the lung microbiota of children with cystic fibrosis (CF) and persistent clones are able to establish chronic infection for years, having a direct deleterious impact on lung function. However, ...
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Last 25 Publications

  1. Avramescu, M, Isnard, P, Temmam, S, Chevalier, A, Bastard, P, Attia, M et al.. Acute tubulointerstitial nephritis with or without uveitis: a novel form of post-acute COVID-19 syndrome in children. Kidney Int. 2023; :. doi: 10.1016/j.kint.2023.02.028. PubMed PMID:36918081 PubMed Central PMC10008186.
  2. Ding, X, Fu, X, Euphrasie, D, Ferroni, A, Sermet-Gaudelus, I, Charbit, A et al.. Genomic analysis of Staphylococcus aureus sequential isolates from lungs of patients with cystic fibrosis. Microbes Infect. 2023; :105124. doi: 10.1016/j.micinf.2023.105124. PubMed PMID:36871931 .
  3. Meyer, S, Puéchal, X, Quesne, G, Marques, I, Jamet, A, Ferroni, A et al.. Contribution of PCR to Differential Diagnosis between Patients with Whipple Disease and Tropheryma whipplei Carriers. J Clin Microbiol. 2023;61 (2):e0145722. doi: 10.1128/jcm.01457-22. PubMed PMID:36656022 PubMed Central PMC9945495.
  4. Riller, Q, Fourgeaud, J, Bruneau, J, De Ravin, SS, Smith, G, Fusaro, M et al.. Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients. J Allergy Clin Immunol. 2023; :. doi: 10.1016/j.jaci.2022.12.822. PubMed PMID:36638922 .
  5. Ramond, E, Lepissier, A, Ding, X, Bouvier, C, Tan, X, Euphrasie, D et al.. Lung-Adapted Staphylococcus aureus Isolates With Dysfunctional Agr System Trigger a Proinflammatory Response. J Infect Dis. 2022;226 (7):1276-1285. doi: 10.1093/infdis/jiac191. PubMed PMID:35524969 .
  6. Barnier, JP, Meyer, J, Kolappan, S, Bouzinba-Ségard, H, Gesbert, G, Jamet, A et al.. The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci U S A. 2021;118 (45):. doi: 10.1073/pnas.2109364118. PubMed PMID:34725157 PubMed Central PMC8609321.
  7. Rytter, H, Jamet, A, Ziveri, J, Ramond, E, Coureuil, M, Lagouge-Roussey, P et al.. The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella. PLoS Pathog. 2021;17 (8):e1009326. doi: 10.1371/journal.ppat.1009326. PubMed PMID:34339477 PubMed Central PMC8360588.
  8. Ramond, E, Jamet, A, Ding, X, Euphrasie, D, Bouvier, C, Lallemant, L et al.. Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the Drosophila Larval Model. mBio. 2021;12 (3):e0027621. doi: 10.1128/mBio.00276-21. PubMed PMID:34126772 PubMed Central PMC8262968.
  9. Regnault, B, Evrard, B, Plu, I, Dacheux, L, Troadec, E, Cozette, P et al.. First Case of Lethal Encephalitis in Western Europe Due to European Bat Lyssavirus Type 1. Clin Infect Dis. 2022;74 (3):461-466. doi: 10.1093/cid/ciab443. PubMed PMID:33991184 .
  10. Rytter, H, Jamet, A, Coureuil, M, Charbit, A, Ramond, E. Which Current and Novel Diagnostic Avenues for Bacterial Respiratory Diseases?. Front Microbiol. 2020;11 :616971. doi: 10.3389/fmicb.2020.616971. PubMed PMID:33362754 PubMed Central PMC7758241.
  11. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 PubMed Central PMC8106705.
  12. Tan, X, Coureuil, M, Charbit, A, Jamet, A. Multitasking Actors of Staphylococcus aureus Metabolism and Virulence. Trends Microbiol. 2020;28 (1):6-9. doi: 10.1016/j.tim.2019.10.013. PubMed PMID:31753539 .
  13. Ramond, E, Jamet, A, Coureuil, M, Charbit, A. Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens. Front Immunol. 2019;10 :2461. doi: 10.3389/fimmu.2019.02461. PubMed PMID:31708919 PubMed Central PMC6819784.
  14. Ziveri, J, Chhuon, C, Jamet, A, Rytter, H, Prigent, G, Tros, F et al.. Critical Role of a Sheath Phosphorylation Site On the Assembly and Function of an Atypical Type VI Secretion System. Mol Cell Proteomics. 2019;18 (12):2418-2432. doi: 10.1074/mcp.RA119.001532. PubMed PMID:31578219 PubMed Central PMC6885697.
  15. Tan, X, Ramond, E, Jamet, A, Barnier, JP, Decaux-Tramoni, B, Dupuis, M et al.. Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection. J Infect Dis. 2019;220 (12):1967-1976. doi: 10.1093/infdis/jiz404. PubMed PMID:31420648 .
  16. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  17. Vidal, C, Moulin, F, Nassif, X, Galmiche, L, Borgel, D, Charbit, A et al.. Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report. BMC Infect Dis. 2019;19 (1):302. doi: 10.1186/s12879-019-3933-3. PubMed PMID:30943907 PubMed Central PMC6446405.
  18. Denis, K, Le Bris, M, Le Guennec, L, Barnier, JP, Faure, C, Gouge, A et al.. Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease. Nat Microbiol. 2019;4 (6):972-984. doi: 10.1038/s41564-019-0395-8. PubMed PMID:30911127 .
  19. Tan, X, Coureuil, M, Ramond, E, Euphrasie, D, Dupuis, M, Tros, F et al.. Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence. Clin Infect Dis. 2019;69 (11):1937-1945. doi: 10.1093/cid/ciz106. PubMed PMID:30753350 .
  20. Jamet, A, Charbit, A, Nassif, X. Antibacterial Toxins: Gram-Positive Bacteria Strike Back!. Trends Microbiol. 2018;26 (2):89-91. doi: 10.1016/j.tim.2017.11.003. PubMed PMID:29174101 .
  21. Capel, E, Barnier, JP, Zomer, AL, Bole-Feysot, C, Nussbaumer, T, Jamet, A et al.. Peripheral blood vessels are a niche for blood-borne meningococci. Virulence. 2017;8 (8):1808-1819. doi: 10.1080/21505594.2017.1391446. PubMed PMID:29099305 PubMed Central PMC5810509.
  22. Jamet, A, Touchon, M, Ribeiro-Gonçalves, B, Carriço, JA, Charbit, A, Nassif, X et al.. A widespread family of polymorphic toxins encoded by temperate phages. BMC Biol. 2017;15 (1):75. doi: 10.1186/s12915-017-0415-1. PubMed PMID:28851366 PubMed Central PMC5576092.
  23. Bille, E, Meyer, J, Jamet, A, Euphrasie, D, Barnier, JP, Brissac, T et al.. A virulence-associated filamentous bacteriophage of Neisseria meningitidis increases host-cell colonisation. PLoS Pathog. 2017;13 (7):e1006495. doi: 10.1371/journal.ppat.1006495. PubMed PMID:28704569 PubMed Central PMC5526601.
  24. Capel, E, Zomer, AL, Nussbaumer, T, Bole, C, Izac, B, Frapy, E et al.. Comprehensive Identification of Meningococcal Genes and Small Noncoding RNAs Required for Host Cell Colonization. mBio. 2016;7 (4):. doi: 10.1128/mBio.01173-16. PubMed PMID:27486197 PubMed Central PMC4981724.
  25. Jamet, A, Nassif, X. Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species. Microb Cell. 2015;2 (3):88-90. doi: 10.15698/mic2015.03.194. PubMed PMID:28357281 PubMed Central PMC5349182.
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