Xavier Nassif

Xavier Nassif, M.D-PhD. is Professor of Microbiology at the Medical School Paris Descartes. He obtained is Medical Degree in 1987 and a PhD at the Pasteur Institute in 1989. After a postdoctoral fellowship he joined in 1992 the « Faculté de Médecine Paris Descartes » where he is heading the Clinical Microbiology Laboratory and the Institut Necker-Enfants Malades.


Last News of the Lab

Barnier_PNAS2021

The minor pilin PilV is necessary for meningococcal type IV pilus adhesion

12/11/2021 .The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus Jean-Philippe Barnier ...
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Congratulation to Audrey LAURENT, Clémence MOUVILLE and Xiali FU

02/08/2021 .Audrey LAURENT and Clémence MOUVILLE have been awarded a PhD Track Grant from BioSPC. Xiali FU has been awarded ...
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PLOS Pathogen Barnier et al 2021

Type IV pilus retraction enables sustained bacteremia

Le 19/02/2021 .Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis ...
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Last 25 Publications

  1. Ramond, E, Lepissier, A, Ding, X, Bouvier, C, Tan, X, Euphrasie, D et al.. Lung-adapted Staphylococcus aureus isolates with dysfunctional agr system trigger a proinflammatory response. J Infect Dis. 2022; :. doi: 10.1093/infdis/jiac191. PubMed PMID:35524969 .
  2. Barnier, JP, Meyer, J, Kolappan, S, Bouzinba-Ségard, H, Gesbert, G, Jamet, A et al.. The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci U S A. 2021;118 (45):. doi: 10.1073/pnas.2109364118. PubMed PMID:34725157 PubMed Central PMC8609321.
  3. Barnier, JP, Euphrasie, D, Join-Lambert, O, Audry, M, Schonherr-Hellec, S, Schmitt, T et al.. Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model. PLoS Pathog. 2021;17 (2):e1009299. doi: 10.1371/journal.ppat.1009299. PubMed PMID:33592056 PubMed Central PMC7909687.
  4. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 PubMed Central PMC8106705.
  5. Dos Santos Souza, I, Maïssa, N, Ziveri, J, Morand, PC, Coureuil, M, Nassif, X et al.. Meningococcal disease: A paradigm of type-IV pilus dependent pathogenesis. Cell Microbiol. 2020;22 (4):e13185. doi: 10.1111/cmi.13185. PubMed PMID:32185901 .
  6. Le Guennec, L, Virion, Z, Bouzinba-Ségard, H, Robbe-Masselot, C, Léonard, R, Nassif, X et al.. Receptor recognition by meningococcal type IV pili relies on a specific complex N-glycan. Proc Natl Acad Sci U S A. 2020;117 (5):2606-2612. doi: 10.1073/pnas.1919567117. PubMed PMID:31964828 PubMed Central PMC7007569.
  7. Audry, M, Robbe-Masselot, C, Barnier, JP, Gachet, B, Saubaméa, B, Schmitt, A et al.. Airway Mucus Restricts Neisseria meningitidis Away from Nasopharyngeal Epithelial Cells and Protects the Mucosa from Inflammation. mSphere. 2019;4 (6):. doi: 10.1128/mSphere.00494-19. PubMed PMID:31801841 PubMed Central PMC6893211.
  8. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Author Correction: Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):17535. doi: 10.1038/s41598-019-54253-4. PubMed PMID:31754179 PubMed Central PMC6872590.
  9. Le Guennec, L, Coureuil, M, Nassif, X, Bourdoulous, S. Strategies used by bacterial pathogens to cross the blood-brain barrier. Cell Microbiol. 2020;22 (1):e13132. doi: 10.1111/cmi.13132. PubMed PMID:31658405 .
  10. Virion, Z, Doly, S, Saha, K, Lambert, M, Guillonneau, F, Bied, C et al.. Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili. Nat Commun. 2019;10 (1):4752. doi: 10.1038/s41467-019-12685-6. PubMed PMID:31628314 PubMed Central PMC6800425.
  11. Tan, X, Ramond, E, Jamet, A, Barnier, JP, Decaux-Tramoni, B, Dupuis, M et al.. Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection. J Infect Dis. 2019;220 (12):1967-1976. doi: 10.1093/infdis/jiz404. PubMed PMID:31420648 .
  12. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  13. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):6516. doi: 10.1038/s41598-019-42751-4. PubMed PMID:31019198 PubMed Central PMC6482305.
  14. Vidal, C, Moulin, F, Nassif, X, Galmiche, L, Borgel, D, Charbit, A et al.. Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report. BMC Infect Dis. 2019;19 (1):302. doi: 10.1186/s12879-019-3933-3. PubMed PMID:30943907 PubMed Central PMC6446405.
  15. Denis, K, Le Bris, M, Le Guennec, L, Barnier, JP, Faure, C, Gouge, A et al.. Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease. Nat Microbiol. 2019;4 (6):972-984. doi: 10.1038/s41564-019-0395-8. PubMed PMID:30911127 .
  16. Tan, X, Coureuil, M, Ramond, E, Euphrasie, D, Dupuis, M, Tros, F et al.. Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence. Clin Infect Dis. 2019;69 (11):1937-1945. doi: 10.1093/cid/ciz106. PubMed PMID:30753350 .
  17. Lécuyer, H, Nassif, X, Coureuil, M. [Meningococcus purpura fulminans, a partially solved mystery]. Med Sci (Paris). 2018;34 (12):1038-1041. doi: 10.1051/medsci/2018288. PubMed PMID:30623761 .
  18. Le Gallou, S, Zhou, Z, Thai, LH, Fritzen, R, de Los Aires, AV, Mégret, J et al.. A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses. J Exp Med. 2018;215 (8):2035-2053. doi: 10.1084/jem.20180977. PubMed PMID:29959173 PubMed Central PMC6080908.
  19. Lécuyer, H, Virion, Z, Barnier, JP, Matczak, S, Bourdoulous, S, Bianchini, E et al.. An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. PLoS Pathog. 2018;14 (4):e1006981. doi: 10.1371/journal.ppat.1006981. PubMed PMID:29630665 PubMed Central PMC5908201.
  20. Jamet, A, Charbit, A, Nassif, X. Antibacterial Toxins: Gram-Positive Bacteria Strike Back!. Trends Microbiol. 2018;26 (2):89-91. doi: 10.1016/j.tim.2017.11.003. PubMed PMID:29174101 .
  21. Capel, E, Barnier, JP, Zomer, AL, Bole-Feysot, C, Nussbaumer, T, Jamet, A et al.. Peripheral blood vessels are a niche for blood-borne meningococci. Virulence. 2017;8 (8):1808-1819. doi: 10.1080/21505594.2017.1391446. PubMed PMID:29099305 PubMed Central PMC5810509.
  22. Wang, F, Coureuil, M, Osinski, T, Orlova, A, Altindal, T, Gesbert, G et al.. Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution. Structure. 2017;25 (9):1423-1435.e4. doi: 10.1016/j.str.2017.07.016. PubMed PMID:28877506 PubMed Central PMC8189185.
  23. Jamet, A, Touchon, M, Ribeiro-Gonçalves, B, Carriço, JA, Charbit, A, Nassif, X et al.. A widespread family of polymorphic toxins encoded by temperate phages. BMC Biol. 2017;15 (1):75. doi: 10.1186/s12915-017-0415-1. PubMed PMID:28851366 PubMed Central PMC5576092.
  24. Bille, E, Meyer, J, Jamet, A, Euphrasie, D, Barnier, JP, Brissac, T et al.. A virulence-associated filamentous bacteriophage of Neisseria meningitidis increases host-cell colonisation. PLoS Pathog. 2017;13 (7):e1006495. doi: 10.1371/journal.ppat.1006495. PubMed PMID:28704569 PubMed Central PMC5526601.
  25. Maïssa, N, Covarelli, V, Janel, S, Durel, B, Simpson, N, Bernard, SC et al.. Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4. Nat Commun. 2017;8 :15764. doi: 10.1038/ncomms15764. PubMed PMID:28569760 PubMed Central PMC5461506.
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