Hervé Lécuyer

Hervé Lécuyer is an associate professor (MCU-PH) at the University of Paris working in the Clinical Microbiology lab of the Hôpital Necker Enfants Malades and in the Research Team 7 of the Institut Necker Enfants Malades. He obtained his PhD in 2011 and worked for several years on Neisseria meningitis interaction with human endothelial cells. He works now on the pathogenesis of Neisseria meningitis to understand the discrepancies between invasive and non invasive isolates.

Last News of the Lab

Congratulation to Audrey LAURENT, Clémence MOUVILLE and Xiali FU

Le 02/08/2021 .Audrey LAURENT and Clémence MOUVILLE have been awarded a PhD Track Grant from BioSPC. Xiali FU has been ...
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PLOS Pathogen Barnier et al 2021

Type IV pilus retraction enables sustained bacteremia

Le 19/02/2021 .Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis ...
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Sialic Acid Mediates β2AR activation by type IV pili

Sialic Acid Mediated Mechanical Activation of β 2 Adrenergic Receptors by Bacterial Pili. Virion et al, Nat Commun, 10 (1), 4752 2019 ...
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Last 25 Publications

  1. Guery, R, Suarez, F, Lanternier, F, Bougnoux, ME, Lecuyer, H, Avettand-Fenoel, V et al.. Poor outcome and high prevalence of invasive fungal infections in patients with adult T-cell leukemia/lymphoma exposed to zidovudine and interferon alfa. Ann Hematol. 2021;100 (11):2813-2824. doi: 10.1007/s00277-021-04622-9. PubMed PMID:34387741 .
  2. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  3. Lécuyer, H, Nassif, X, Coureuil, M. [Meningococcus purpura fulminans, a partially solved mystery]. Med Sci (Paris). 2018;34 (12):1038-1041. doi: 10.1051/medsci/2018288. PubMed PMID:30623761 .
  4. Etienne, N, Bret, L, Le Brun, C, Lecuyer, H, Moraly, J, Lanternier, F et al.. Disseminated Spiroplasma apis Infection in Patient with Agammaglobulinemia, France. Emerg Infect Dis. 2018;24 (12):2382-2386. doi: 10.3201/eid2412.180567. PubMed PMID:30457541 PubMed Central PMC6256403.
  5. Lécuyer, H, Virion, Z, Barnier, JP, Matczak, S, Bourdoulous, S, Bianchini, E et al.. An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. PLoS Pathog. 2018;14 (4):e1006981. doi: 10.1371/journal.ppat.1006981. PubMed PMID:29630665 PubMed Central PMC5908201.
  6. Capel, E, Barnier, JP, Zomer, AL, Bole-Feysot, C, Nussbaumer, T, Jamet, A et al.. Peripheral blood vessels are a niche for blood-borne meningococci. Virulence. 2017;8 (8):1808-1819. doi: 10.1080/21505594.2017.1391446. PubMed PMID:29099305 PubMed Central PMC5810509.
  7. Lécuyer, H, Borgel, D, Nassif, X, Coureuil, M. Pathogenesis of meningococcal purpura fulminans. Pathog Dis. 2017;75 (3):. doi: 10.1093/femspd/ftx027. PubMed PMID:28334263 .
  8. Coureuil, M, Lécuyer, H, Bourdoulous, S, Nassif, X. A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers. Nat Rev Microbiol. 2017;15 (3):149-159. doi: 10.1038/nrmicro.2016.178. PubMed PMID:28090076 .
  9. Guet-Revillet, H, Tomini, E, Emirian, A, Join-Lambert, O, Lécuyer, H, Zahar, JR et al.. Piperacillin/tazobactam as an alternative antibiotic therapy to carbapenems in the treatment of urinary tract infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae: an in silico pharmacokinetic study. Int J Antimicrob Agents. 2017;49 (1):62-66. doi: 10.1016/j.ijantimicag.2016.09.027. PubMed PMID:27876276 .
  10. Chaussade, H, Lebeaux, D, Gras, G, Catherinot, E, Rammaert, B, Poiree, S et al.. Nocardia Arthritis: 3 Cases and Literature Review. Medicine (Baltimore). 2015;94 (42):e1671. doi: 10.1097/MD.0000000000001671. PubMed PMID:26496274 PubMed Central PMC4620750.
  11. Pilmis, B, Lécuyer, H, Lortholary, O, Charlier, C. Enterococcus faecalis-related prostatitis successfully treated with moxifloxacin. Antimicrob Agents Chemother. 2015;59 (11):7156-7. doi: 10.1128/AAC.01988-15. PubMed PMID:26349832 PubMed Central PMC4604358.
  12. Girlich, D, Nordmann, P, Lécuyer, H, Berche, P, Marmorat-Khuong, A, Gros, I et al.. Multiple colonization with highly resistant bacteria: carbapenemase-producing Enterobacteriaceae, carbapenemase-producing Pseudomonas aeruginosa, carbapenemase-producing Acinetobacter baumannii, and glycopeptide-resistant Enterococcus faecium. Diagn Microbiol Infect Dis. 2015;81 (3):217-8. doi: 10.1016/j.diagmicrobio.2014.12.002. PubMed PMID:25547540 .
  13. Desjardins, A, Parize, P, Angebault, C, Lécuyer, H, Lortholary, O, Bougnoux, ME et al.. Lack of 1-3-B-D-glucan detection in adults with bacteraemia. Med Mycol. 2015;53 (4):405-8. doi: 10.1093/mmy/myu067. PubMed PMID:25541560 .
  14. Ghosn, J, Leruez-Ville, M, Blanche, J, Delobelle, A, Beaudoux, C, Mascard, L et al.. HIV-1 DNA levels in peripheral blood mononuclear cells and cannabis use are associated with intermittent HIV shedding in semen of men who have sex with men on successful antiretroviral regimens. Clin Infect Dis. 2014;58 (12):1763-70. doi: 10.1093/cid/ciu187. PubMed PMID:24647014 .
  15. Join-Lambert, O, Lecuyer, H, Miller, F, Lelievre, L, Jamet, A, Furio, L et al.. Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans. J Infect Dis. 2013;208 (10):1590-7. doi: 10.1093/infdis/jit301. PubMed PMID:23840047 .
  16. Coureuil, M, Join-Lambert, O, Lécuyer, H, Bourdoulous, S, Marullo, S, Nassif, X et al.. Pathogenesis of meningococcemia. Cold Spring Harb Perspect Med. 2013;3 (6):. doi: 10.1101/cshperspect.a012393. PubMed PMID:23732856 PubMed Central PMC3662350.
  17. Rivard-Yazigi, L, Zahar, JR, Le Guillou, S, Chalouhi, C, Lecuyer, H, Bureau, C et al.. Risk factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae carriage at admission in an infant cohort at a tertiary teaching hospital in France. Am J Infect Control. 2013;41 (9):844-5. doi: 10.1016/j.ajic.2012.11.016. PubMed PMID:23465604 .
  18. Schnell, D, Lécuyer, H, Geeraerts, T, Dumenil, AS, Bille, E, Mercier, FJ et al.. Preliminary evaluation of a new clinical algorithm to interpret blood cultures growing coagulase-negative staphylococci. Scand J Infect Dis. 2013;45 (7):562-6. doi: 10.3109/00365548.2013.765590. PubMed PMID:23373849 .
  19. Miller, F, Lécuyer, H, Join-Lambert, O, Bourdoulous, S, Marullo, S, Nassif, X et al.. Neisseria meningitidis colonization of the brain endothelium and cerebrospinal fluid invasion. Cell Microbiol. 2013;15 (4):512-9. doi: 10.1111/cmi.12082. PubMed PMID:23189983 .
  20. Prinapori, R, Guinaud, J, Khalil, A, Lecuyer, H, Gendrel, D, Lortholary, O et al.. Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae. Am J Infect Control. 2013;41 (3):259-60. doi: 10.1016/j.ajic.2012.03.035. PubMed PMID:23062579 .
  21. Dupin, N, Lecuyer, H, Carlotti, A, Poyart, C, Coureuil, M, Chanal, J et al.. Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. Clin Infect Dis. 2012;54 (8):1162-5. doi: 10.1093/cid/cis120. PubMed PMID:22412064 .
  22. Coureuil, M, Join-Lambert, O, Lécuyer, H, Bourdoulous, S, Marullo, S, Nassif, X et al.. Mechanism of meningeal invasion by Neisseria meningitidis. Virulence. ;3 (2):164-72. doi: 10.4161/viru.18639. PubMed PMID:22366962 PubMed Central PMC3396695.
  23. Guet-Revillet, H, Le Monnier, A, Breton, N, Descamps, P, Lecuyer, H, Alaabouche, I et al.. Environmental contamination with extended-spectrum β-lactamases: is there any difference between Escherichia coli and Klebsiella spp?. Am J Infect Control. 2012;40 (9):845-8. doi: 10.1016/j.ajic.2011.10.007. PubMed PMID:22325483 .
  24. Lécuyer, H, Nassif, X, Coureuil, M. Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells. Infect Immun. 2012;80 (1):175-86. doi: 10.1128/IAI.05837-11. PubMed PMID:22064711 PubMed Central PMC3255667.
  25. Bonnin, RA, Potron, A, Poirel, L, Lecuyer, H, Neri, R, Nordmann, P et al.. PER-7, an extended-spectrum beta-lactamase with increased activity toward broad-spectrum cephalosporins in Acinetobacter baumannii. Antimicrob Agents Chemother. 2011;55 (5):2424-7. doi: 10.1128/AAC.01795-10. PubMed PMID:21383087 PubMed Central PMC3088246.
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