Hervé Lécuyer

Hervé Lécuyer is an associate professor (MCU-PH) at the University of Paris working in the Clinical Microbiology lab of the Hôpital Necker Enfants Malades and in the Research Team 7 of the Institut Necker Enfants Malades. He obtained his PhD in 2011 and worked for several years on Neisseria meningitis interaction with human endothelial cells. He works now on the pathogenesis of Neisseria meningitis to understand the discrepancies between invasive and non invasive isolates.

Last News of the Lab

Grant ANR PRC and PRME

24/07/2023 .Emmanuelle Bille was granted ANR PRME for her project on N. meningitidis and filamentous phage biology. The Neisseria group ...
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Congratulation to Morgane Wuckelt and Elif UYAR

24/07/2023 .Morgane Wuckelt and Elif Uyar have been awarded a PhD Track Grant from BioSPC. We are all very proud ...
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Engineered human microvasculature to study human infectious diseases

27/03/2023 . Implantation of engineered human microvasculature to study human infectious diseases in mouse models.Sophia Schönherr-Hellec et al iScience 2023 ...
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Team Members

Last 25 Publications

  1. Thizy, G, Flahault, A, Scemla, A, Roux, O, Jarraud, S, Lebeaux, D et al.. Legionnaires Disease in Solid Organ Transplant Recipients: A Decade-Long Nationwide Study in France. Chest. 2024;165 (3):507-520. doi: 10.1016/j.chest.2023.09.033. PubMed PMID:37839586 .
  2. Faury, H, Stanzelova, A, Ferroni, A, Belhous, K, Morand, P, Toubiana, J et al.. Mycobacterium canettii Tuberculosis Lymphadenopathy in a 3-Year-old Child. Pediatr Infect Dis J. 2023;42 (9):e345-e347. doi: 10.1097/INF.0000000000003983. PubMed PMID:37235762 .
  3. Roupie, AL, Lafont, E, Fraitag, S, Ferroni, A, Lécuyer, H, Boccara, O et al.. Recurrent Cellulitis Revealing Helicobacter cinaedi in Patient on Ibrutinib Therapy, France. Emerg Infect Dis. 2023;29 (3):640-641. doi: 10.3201/eid2903.221329. PubMed PMID:36823687 PubMed Central PMC9973678.
  4. Pons, S, Frapy, E, Sereme, Y, Gaultier, C, Lebreton, F, Kropec, A et al.. A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates. EBioMedicine. 2023;88 :104439. doi: 10.1016/j.ebiom.2023.104439. PubMed PMID:36709579 PubMed Central PMC9900374.
  5. Guery, R, Suarez, F, Lanternier, F, Bougnoux, ME, Lecuyer, H, Avettand-Fenoel, V et al.. Poor outcome and high prevalence of invasive fungal infections in patients with adult T-cell leukemia/lymphoma exposed to zidovudine and interferon alfa. Ann Hematol. 2021;100 (11):2813-2824. doi: 10.1007/s00277-021-04622-9. PubMed PMID:34387741 .
  6. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  7. Lécuyer, H, Nassif, X, Coureuil, M. [Meningococcus purpura fulminans, a partially solved mystery]. Med Sci (Paris). 2018;34 (12):1038-1041. doi: 10.1051/medsci/2018288. PubMed PMID:30623761 .
  8. Etienne, N, Bret, L, Le Brun, C, Lecuyer, H, Moraly, J, Lanternier, F et al.. Disseminated Spiroplasma apis Infection in Patient with Agammaglobulinemia, France. Emerg Infect Dis. 2018;24 (12):2382-2386. doi: 10.3201/eid2412.180567. PubMed PMID:30457541 PubMed Central PMC6256403.
  9. Lécuyer, H, Virion, Z, Barnier, JP, Matczak, S, Bourdoulous, S, Bianchini, E et al.. An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. PLoS Pathog. 2018;14 (4):e1006981. doi: 10.1371/journal.ppat.1006981. PubMed PMID:29630665 PubMed Central PMC5908201.
  10. Capel, E, Barnier, JP, Zomer, AL, Bole-Feysot, C, Nussbaumer, T, Jamet, A et al.. Peripheral blood vessels are a niche for blood-borne meningococci. Virulence. 2017;8 (8):1808-1819. doi: 10.1080/21505594.2017.1391446. PubMed PMID:29099305 PubMed Central PMC5810509.
  11. Lécuyer, H, Borgel, D, Nassif, X, Coureuil, M. Pathogenesis of meningococcal purpura fulminans. Pathog Dis. 2017;75 (3):. doi: 10.1093/femspd/ftx027. PubMed PMID:28334263 .
  12. Coureuil, M, Lécuyer, H, Bourdoulous, S, Nassif, X. A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers. Nat Rev Microbiol. 2017;15 (3):149-159. doi: 10.1038/nrmicro.2016.178. PubMed PMID:28090076 .
  13. Guet-Revillet, H, Tomini, E, Emirian, A, Join-Lambert, O, Lécuyer, H, Zahar, JR et al.. Piperacillin/tazobactam as an alternative antibiotic therapy to carbapenems in the treatment of urinary tract infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae: an in silico pharmacokinetic study. Int J Antimicrob Agents. 2017;49 (1):62-66. doi: 10.1016/j.ijantimicag.2016.09.027. PubMed PMID:27876276 .
  14. Chaussade, H, Lebeaux, D, Gras, G, Catherinot, E, Rammaert, B, Poiree, S et al.. Nocardia Arthritis: 3 Cases and Literature Review. Medicine (Baltimore). 2015;94 (42):e1671. doi: 10.1097/MD.0000000000001671. PubMed PMID:26496274 PubMed Central PMC4620750.
  15. Pilmis, B, Lécuyer, H, Lortholary, O, Charlier, C. Enterococcus faecalis-related prostatitis successfully treated with moxifloxacin. Antimicrob Agents Chemother. 2015;59 (11):7156-7. doi: 10.1128/AAC.01988-15. PubMed PMID:26349832 PubMed Central PMC4604358.
  16. Girlich, D, Nordmann, P, Lécuyer, H, Berche, P, Marmorat-Khuong, A, Gros, I et al.. Multiple colonization with highly resistant bacteria: carbapenemase-producing Enterobacteriaceae, carbapenemase-producing Pseudomonas aeruginosa, carbapenemase-producing Acinetobacter baumannii, and glycopeptide-resistant Enterococcus faecium. Diagn Microbiol Infect Dis. 2015;81 (3):217-8. doi: 10.1016/j.diagmicrobio.2014.12.002. PubMed PMID:25547540 .
  17. Desjardins, A, Parize, P, Angebault, C, Lécuyer, H, Lortholary, O, Bougnoux, ME et al.. Lack of 1-3-B-D-glucan detection in adults with bacteraemia. Med Mycol. 2015;53 (4):405-8. doi: 10.1093/mmy/myu067. PubMed PMID:25541560 .
  18. Ghosn, J, Leruez-Ville, M, Blanche, J, Delobelle, A, Beaudoux, C, Mascard, L et al.. HIV-1 DNA levels in peripheral blood mononuclear cells and cannabis use are associated with intermittent HIV shedding in semen of men who have sex with men on successful antiretroviral regimens. Clin Infect Dis. 2014;58 (12):1763-70. doi: 10.1093/cid/ciu187. PubMed PMID:24647014 .
  19. Join-Lambert, O, Lecuyer, H, Miller, F, Lelievre, L, Jamet, A, Furio, L et al.. Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans. J Infect Dis. 2013;208 (10):1590-7. doi: 10.1093/infdis/jit301. PubMed PMID:23840047 .
  20. Coureuil, M, Join-Lambert, O, Lécuyer, H, Bourdoulous, S, Marullo, S, Nassif, X et al.. Pathogenesis of meningococcemia. Cold Spring Harb Perspect Med. 2013;3 (6):. doi: 10.1101/cshperspect.a012393. PubMed PMID:23732856 PubMed Central PMC3662350.
  21. Rivard-Yazigi, L, Zahar, JR, Le Guillou, S, Chalouhi, C, Lecuyer, H, Bureau, C et al.. Risk factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae carriage at admission in an infant cohort at a tertiary teaching hospital in France. Am J Infect Control. 2013;41 (9):844-5. doi: 10.1016/j.ajic.2012.11.016. PubMed PMID:23465604 .
  22. Schnell, D, Lécuyer, H, Geeraerts, T, Dumenil, AS, Bille, E, Mercier, FJ et al.. Preliminary evaluation of a new clinical algorithm to interpret blood cultures growing coagulase-negative staphylococci. Scand J Infect Dis. 2013;45 (7):562-6. doi: 10.3109/00365548.2013.765590. PubMed PMID:23373849 .
  23. Miller, F, Lécuyer, H, Join-Lambert, O, Bourdoulous, S, Marullo, S, Nassif, X et al.. Neisseria meningitidis colonization of the brain endothelium and cerebrospinal fluid invasion. Cell Microbiol. 2013;15 (4):512-9. doi: 10.1111/cmi.12082. PubMed PMID:23189983 .
  24. Prinapori, R, Guinaud, J, Khalil, A, Lecuyer, H, Gendrel, D, Lortholary, O et al.. Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae. Am J Infect Control. 2013;41 (3):259-60. doi: 10.1016/j.ajic.2012.03.035. PubMed PMID:23062579 .
  25. Dupin, N, Lecuyer, H, Carlotti, A, Poyart, C, Coureuil, M, Chanal, J et al.. Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. Clin Infect Dis. 2012;54 (8):1162-5. doi: 10.1093/cid/cis120. PubMed PMID:22412064 .
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