Emmanuelle Bille

Emmanuelle Bille is a pharmacist and microbiologist (phD, PD). She is an associate professor (MCU-PH) in the Unit of « Pathogenesis of Systemic Infections » (U1151-E7, INEM, Paris) and an academic practitioner in the Microbiology Laboratory of the Necker Children’s Hospital.
Besides her hospital activities at the Necker-Enfants Malades Hospital, she has pursued fundamental research activities on Neisseriameningitidis virulence since 2003. Emmanuelle Bille highlighted a filamentous bacteriophage, designated MDAΦ for Meningococcal Disease Associated, associated with invasive diseases caused by N. meningitidis. The presence of the prophage MDA in the genome of a strain, via the production of viruses, increases colonization of meningococci onto monolayers of epithelial cells. So, MDAΦ seems increase bacterial colonization in the mucosa at the site-of-entry, and increase the occurrence of diseases.

Emmanuelle Bille

Last News of the Lab

Type IV Pili recognize a Complex N-glycan

Receptor Recognition by Meningococcal Type IV Pili Relies on a Specific Complex N-glycan. Leguennec et al Proc Natl Acad Sci ...
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Sialic Acid Mediates β2AR activation by type IV pili

Sialic Acid Mediated Mechanical Activation of β 2 Adrenergic Receptors by Bacterial Pili. Virion et al, Nat Commun, 10 (1), 4752 2019 ...
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PLOS Pathogen Barnier et al 2021

Type IV pilus retraction enables sustained bacteremia

Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a ...
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Team Members

Last Publications

  1. Farfour, E, Si Larbi, AG, Cattoir, V, Corvec, S, Guillard, T, Grillon, A et al.. Temocillin susceptibility among Enterobacterales strains recovered from blood culture in France. Diagn Microbiol Infect Dis. 2021;100 (3):115368. doi: 10.1016/j.diagmicrobio.2021.115368. PubMed PMID:33813355 .
  2. Lefèvre, CR, Pelletier, R, Le Monnier, A, Corvec, S, Bille, E, Potron, A et al.. Clinical relevance and antimicrobial susceptibility profile of the unknown human pathogen Corynebacterium aurimucosum. J Med Microbiol. 2021;70 (3):. doi: 10.1099/jmm.0.001334. PubMed PMID:33734955 .
  3. Cormontagne, D, Rigourd, V, Vidic, J, Rizzotto, F, Bille, E, Ramarao, N et al.. Bacillus cereus Induces Severe Infections in Preterm Neonates: Implication at the Hospital and Human Milk Bank Level. Toxins (Basel). 2021;13 (2):. doi: 10.3390/toxins13020123. PubMed PMID:33562185 PubMed Central PMC7915446.
  4. Poline, J, Postaire, M, Parize, P, Pilmis, B, Bille, E, Zahar, JR et al.. Stewardship program on carbapenem prescriptions in a tertiary hospital for adults and children in France: a cohort study. Eur J Clin Microbiol Infect Dis. 2021; :. doi: 10.1007/s10096-020-04103-3. PubMed PMID:33389261 PubMed Central PMC7778866.
  5. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 .
  6. Decalonne, M, Dos Santos, S, Gimenes, R, Goube, F, Abadie, G, Aberrane, S et al.. Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units. Eur J Clin Microbiol Infect Dis. 2020;39 (11):2185-2194. doi: 10.1007/s10096-020-03925-5. PubMed PMID:32519215 PubMed Central PMC7561542.
  7. Pilmis, B, Alby-Laurent, F, Fasola, ML, Seegers, V, Guery, R, Guet-Revillet, H et al.. Pseudomonas aeruginosa bloodstream infections in children: a 9-year retrospective study. Eur J Pediatr. 2020;179 (8):1247-1254. doi: 10.1007/s00431-020-03598-4. PubMed PMID:32080759 .
  8. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Author Correction: Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):17535. doi: 10.1038/s41598-019-54253-4. PubMed PMID:31754179 PubMed Central PMC6872590.
  9. Rapp, M, Urien, S, Foissac, F, Béranger, A, Bouazza, N, Benaboud, S et al.. Population pharmacokinetics of meropenem in critically ill children with different renal functions. Eur J Clin Pharmacol. 2020;76 (1):61-71. doi: 10.1007/s00228-019-02761-7. PubMed PMID:31654149 .
  10. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  11. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):6516. doi: 10.1038/s41598-019-42751-4. PubMed PMID:31019198 PubMed Central PMC6482305.
  12. Brunel, M, Leclerc-Mercier, S, Barnier, JP, Bille, E, Sberro-Soussan, R, Legendre, C et al.. The Case | Posttransplant upper limb inflammatory nodules. Kidney Int. 2019;95 (3):721-722. doi: 10.1016/j.kint.2018.10.012. PubMed PMID:30784666 .
  13. Le Gallou, S, Zhou, Z, Thai, LH, Fritzen, R, de Los Aires, AV, Mégret, J et al.. A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses. J Exp Med. 2018;215 (8):2035-2053. doi: 10.1084/jem.20180977. PubMed PMID:29959173 PubMed Central PMC6080908.
  14. Béranger, A, Benaboud, S, Urien, S, Moulin, F, Bille, E, Lesage, F et al.. Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children with Normal and Augmented Renal Clearance. Clin Pharmacokinet. 2019;58 (2):223-233. doi: 10.1007/s40262-018-0682-1. PubMed PMID:29862466 .
  15. Bille, E, Meyer, J, Jamet, A, Euphrasie, D, Barnier, JP, Brissac, T et al.. A virulence-associated filamentous bacteriophage of Neisseria meningitidis increases host-cell colonisation. PLoS Pathog. 2017;13 (7):e1006495. doi: 10.1371/journal.ppat.1006495. PubMed PMID:28704569 PubMed Central PMC5526601.
  16. Capel, E, Zomer, AL, Nussbaumer, T, Bole, C, Izac, B, Frapy, E et al.. Comprehensive Identification of Meningococcal Genes and Small Noncoding RNAs Required for Host Cell Colonization. mBio. 2016;7 (4):. doi: 10.1128/mBio.01173-16. PubMed PMID:27486197 PubMed Central PMC4981724.
  17. Meyer, J, Brissac, T, Frapy, E, Omer, H, Euphrasie, D, Bonavita, A et al.. Characterization of MDAΦ, a temperate filamentous bacteriophage of Neisseria meningitidis. Microbiology (Reading). 2016;162 (2):268-282. doi: 10.1099/mic.0.000215. PubMed PMID:26602366 .
  18. Schnell, D, Lécuyer, H, Geeraerts, T, Dumenil, AS, Bille, E, Mercier, FJ et al.. Preliminary evaluation of a new clinical algorithm to interpret blood cultures growing coagulase-negative staphylococci. Scand J Infect Dis. 2013;45 (7):562-6. doi: 10.3109/00365548.2013.765590. PubMed PMID:23373849 .
  19. Jacquier, H, Le Monnier, A, Carbonnelle, E, Corvec, S, Illiaquer, M, Bille, E et al.. In vitro antimicrobial activity of "last-resort" antibiotics against unusual nonfermenting Gram-negative bacilli clinical isolates. Microb Drug Resist. 2012;18 (4):396-401. doi: 10.1089/mdr.2011.0195. PubMed PMID:22335615 .
  20. Fihman, V, Le Monnier, A, Corvec, S, Jaureguy, F, Tankovic, J, Jacquier, H et al.. Stenotrophomonas maltophilia--the most worrisome threat among unusual non-fermentative gram-negative bacilli from hospitalized patients: a prospective multicenter study. J Infect. 2012;64 (4):391-8. doi: 10.1016/j.jinf.2012.01.001. PubMed PMID:22245400 .
  21. Bussone, G, Brossier, F, Roudiere, L, Bille, E, Sekkal, N, Charlier, C et al.. Recurrent Mycobacterium avium infection after seven years of latency in a HIV-infected patient receiving efficient antiretroviral therapy. J Infect. 2012;64 (6):613-7. doi: 10.1016/j.jinf.2011.12.020. PubMed PMID:22230736 .
  22. Couloigner, V, Levy, C, François, M, Bidet, P, Hausdorff, WP, Pascal, T et al.. Pathogens implicated in acute otitis media failures after 7-valent pneumococcal conjugate vaccine implementation in France: distribution, serotypes, and resistance levels. Pediatr Infect Dis J. 2012;31 (2):154-8. doi: 10.1097/INF.0b013e3182357c8d. PubMed PMID:21983212 .
  23. Guillet-Caruba, C, Cheikhelard, A, Guillet, M, Bille, E, Descamps, P, Yin, L et al.. Bacteriologic epidemiology and empirical treatment of pediatric complicated appendicitis. Diagn Microbiol Infect Dis. 2011;69 (4):376-81. doi: 10.1016/j.diagmicrobio.2010.11.003. PubMed PMID:21396532 .
  24. Omer, H, Rose, G, Jolley, KA, Frapy, E, Zahar, JR, Maiden, MC et al.. Genotypic and phenotypic modifications of Neisseria meningitidis after an accidental human passage. PLoS One. 2011;6 (2):e17145. doi: 10.1371/journal.pone.0017145. PubMed PMID:21386889 PubMed Central PMC3046118.
  25. Lotz, A, Ferroni, A, Beretti, JL, Dauphin, B, Carbonnelle, E, Guet-Revillet, H et al.. Rapid identification of mycobacterial whole cells in solid and liquid culture media by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol. 2010;48 (12):4481-6. doi: 10.1128/JCM.01397-10. PubMed PMID:20943874 PubMed Central PMC3008439.
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