Emmanuelle Bille

Emmanuelle Bille is a pharmacist and microbiologist (phD, PD). She is an associate professor (MCU-PH) in the Unit of « Pathogenesis of Systemic Infections » (U1151-E7, INEM, Paris) and an academic practitioner in the Microbiology Laboratory of the Necker Children’s Hospital.
Besides her hospital activities at the Necker-Enfants Malades Hospital, she has pursued fundamental research activities on Neisseriameningitidis virulence since 2003. Emmanuelle Bille highlighted a filamentous bacteriophage, designated MDAΦ for Meningococcal Disease Associated, associated with invasive diseases caused by N. meningitidis. The presence of the prophage MDA in the genome of a strain, via the production of viruses, increases colonization of meningococci onto monolayers of epithelial cells. So, MDAΦ seems increase bacterial colonization in the mucosa at the site-of-entry, and increase the occurrence of diseases.

Emmanuelle Bille

Last News of the Lab

Mechanical Activation of the β2-Adrenergic Receptor by Meningococci (Review)

02/05/2022 .Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe ...
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The minor pilin PilV is necessary for meningococcal type IV pilus adhesion

12/11/2021 .The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus Jean-Philippe Barnier ...
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Congratulation to Audrey LAURENT, Clémence MOUVILLE and Xiali FU

02/08/2021 .Audrey LAURENT and Clémence MOUVILLE have been awarded a PhD Track Grant from BioSPC. Xiali FU has been awarded ...
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Last Publications

  1. Debray, A, Callot, D, Hirt, D, Bille, E, Renolleau, S, Chouchana, L et al.. Beta-lactam exposure and safety in intermittent or continuous infusion in critically ill children: an observational monocenter study. Eur J Pediatr. 2022; :. doi: 10.1007/s00431-022-04716-0. PubMed PMID:36422708 .
  2. Thy, M, Urien, S, Foissac, F, Bouazza, N, Gana, I, Bille, E et al.. Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy. Antimicrob Agents Chemother. 2022; :e0113522. doi: 10.1128/aac.01135-22. PubMed PMID:36342152 .
  3. Thy, M, Urien, S, Bouazza, N, Foissac, F, Gana, I, Bille, E et al.. Meropenem Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy. Clin Pharmacokinet. 2022;61 (11):1609-1621. doi: 10.1007/s40262-022-01179-2. PubMed PMID:36251162 .
  4. Pizzato, J, Tang, W, Bernabeu, S, Bonnin, RA, Bille, E, Farfour, E et al.. Discrimination of Escherichia coli, Shigella flexneri, and Shigella sonnei using lipid profiling by MALDI-TOF mass spectrometry paired with machine learning. Microbiologyopen. 2022;11 (4):e1313. doi: 10.1002/mbo3.1313. PubMed PMID:36004556 PubMed Central PMC9405496.
  5. de Cacqueray, N, Hirt, D, Zheng, Y, Bille, E, Leger, PL, Rambaud, J et al.. Cefepime population pharmacokinetics and dosing regimen optimization in critically ill children with different renal function. Clin Microbiol Infect. 2022;28 (10):1389.e1-1389.e7. doi: 10.1016/j.cmi.2022.05.007. PubMed PMID:35605841 .
  6. Farfour, E, Dortet, L, Guillard, T, Chatelain, N, Poisson, A, Mizrahi, A et al.. Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France. Pathogens. 2022;11 (3):. doi: 10.3390/pathogens11030356. PubMed PMID:35335681 PubMed Central PMC8949168.
  7. de Cacqueray, N, Boujaafar, S, Bille, E, Moulin, F, Gana, I, Benaboud, S et al.. Therapeutic Drug Monitoring of Antibiotics in Critically Ill Children: An Observational Study in a Pediatric Intensive Care Unit. Ther Drug Monit. 2022;44 (2):319-327. doi: 10.1097/FTD.0000000000000918. PubMed PMID:35292609 .
  8. Beauruelle, C, Plouzeau, C, Grillon, A, Isnard, C, Corvec, S, Degand, N et al.. Capnocytophaga zoonotic infections: a 10-year retrospective study (the French CANCAN study). Eur J Clin Microbiol Infect Dis. 2022;41 (4):581-588. doi: 10.1007/s10096-022-04402-x. PubMed PMID:35064380 .
  9. Lombes, A, Bonnin, RA, Laurent, F, Guet-Revillet, H, Bille, E, Cattoir, V et al.. High Prevalence of OXA-23 Carbapenemase-Producing Proteus mirabilis among Amoxicillin-Clavulanate-Resistant Isolates in France. Antimicrob Agents Chemother. 2022;66 (2):e0198321. doi: 10.1128/AAC.01983-21. PubMed PMID:34930033 PubMed Central PMC8846483.
  10. Tinévez, C, Velardo, F, Ranc, AG, Dubois, D, Pailhoriès, H, Codde, C et al.. Retrospective Multicentric Study on Campylobacter spp. Bacteremia in France: The Campylobacteremia Study. Clin Infect Dis. 2022;75 (4):702-709. doi: 10.1093/cid/ciab983. PubMed PMID:34849656 .
  11. Barnier, JP, Meyer, J, Kolappan, S, Bouzinba-Ségard, H, Gesbert, G, Jamet, A et al.. The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci U S A. 2021;118 (45):. doi: 10.1073/pnas.2109364118. PubMed PMID:34725157 PubMed Central PMC8609321.
  12. Runyo, F, Beaudoin, MC, Hammadi, B, Morgand, M, Driessen, M, Sellier, Y et al.. Procalcitonin use for the screening of bacterial infections in pregnant women in the emergency ward: A prospective study. J Infect. 2021;83 (3):e4-e5. doi: 10.1016/j.jinf.2021.07.005. PubMed PMID:34271061 .
  13. Medjebeur Hanna, R, Levy, M, Bille, E, Hennequin, C, Lesage, F, Naudin, J et al.. Assessment of the Effects of a High Amikacin Dose on Plasma Peak Concentration in Critically Ill Children. Paediatr Drugs. 2021;23 (4):395-401. doi: 10.1007/s40272-021-00456-0. PubMed PMID:34142330 .
  14. Farfour, E, Si Larbi, AG, Cattoir, V, Corvec, S, Guillard, T, Grillon, A et al.. Temocillin susceptibility among Enterobacterales strains recovered from blood culture in France. Diagn Microbiol Infect Dis. 2021;100 (3):115368. doi: 10.1016/j.diagmicrobio.2021.115368. PubMed PMID:33813355 .
  15. Lefèvre, CR, Pelletier, R, Le Monnier, A, Corvec, S, Bille, E, Potron, A et al.. Clinical relevance and antimicrobial susceptibility profile of the unknown human pathogen Corynebacterium aurimucosum. J Med Microbiol. 2021;70 (3):. doi: 10.1099/jmm.0.001334. PubMed PMID:33734955 .
  16. Cormontagne, D, Rigourd, V, Vidic, J, Rizzotto, F, Bille, E, Ramarao, N et al.. Bacillus cereus Induces Severe Infections in Preterm Neonates: Implication at the Hospital and Human Milk Bank Level. Toxins (Basel). 2021;13 (2):. doi: 10.3390/toxins13020123. PubMed PMID:33562185 PubMed Central PMC7915446.
  17. Poline, J, Postaire, M, Parize, P, Pilmis, B, Bille, E, Zahar, JR et al.. Stewardship program on carbapenem prescriptions in a tertiary hospital for adults and children in France: a cohort study. Eur J Clin Microbiol Infect Dis. 2021;40 (5):1039-1048. doi: 10.1007/s10096-020-04103-3. PubMed PMID:33389261 PubMed Central PMC7778866.
  18. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 PubMed Central PMC8106705.
  19. Decalonne, M, Dos Santos, S, Gimenes, R, Goube, F, Abadie, G, Aberrane, S et al.. Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units. Eur J Clin Microbiol Infect Dis. 2020;39 (11):2185-2194. doi: 10.1007/s10096-020-03925-5. PubMed PMID:32519215 PubMed Central PMC7561542.
  20. Pilmis, B, Alby-Laurent, F, Fasola, ML, Seegers, V, Guery, R, Guet-Revillet, H et al.. Pseudomonas aeruginosa bloodstream infections in children: a 9-year retrospective study. Eur J Pediatr. 2020;179 (8):1247-1254. doi: 10.1007/s00431-020-03598-4. PubMed PMID:32080759 .
  21. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Author Correction: Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):17535. doi: 10.1038/s41598-019-54253-4. PubMed PMID:31754179 PubMed Central PMC6872590.
  22. Rapp, M, Urien, S, Foissac, F, Béranger, A, Bouazza, N, Benaboud, S et al.. Population pharmacokinetics of meropenem in critically ill children with different renal functions. Eur J Clin Pharmacol. 2020;76 (1):61-71. doi: 10.1007/s00228-019-02761-7. PubMed PMID:31654149 .
  23. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  24. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):6516. doi: 10.1038/s41598-019-42751-4. PubMed PMID:31019198 PubMed Central PMC6482305.
  25. Brunel, M, Leclerc-Mercier, S, Barnier, JP, Bille, E, Sberro-Soussan, R, Legendre, C et al.. The Case | Posttransplant upper limb inflammatory nodules. Kidney Int. 2019;95 (3):721-722. doi: 10.1016/j.kint.2018.10.012. PubMed PMID:30784666 .
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