Emmanuelle Bille

Emmanuelle Bille is a pharmacist and microbiologist (phD, PD). She is an associate professor (MCU-PH) in the Unit of « Pathogenesis of Systemic Infections » (U1151-E7, INEM, Paris) and an academic practitioner in the Microbiology Laboratory of the Necker Children’s Hospital.
Besides her hospital activities at the Necker-Enfants Malades Hospital, she has pursued fundamental research activities on Neisseriameningitidis virulence since 2003. Emmanuelle Bille highlighted a filamentous bacteriophage, designated MDAΦ for Meningococcal Disease Associated, associated with invasive diseases caused by N. meningitidis. The presence of the prophage MDA in the genome of a strain, via the production of viruses, increases colonization of meningococci onto monolayers of epithelial cells. So, MDAΦ seems increase bacterial colonization in the mucosa at the site-of-entry, and increase the occurrence of diseases.

Emmanuelle Bille

Last News of the Lab

Barnier_PNAS2021

The minor pilin PilV is necessary for meningococcal type IV pilus adhesion

12/11/2021 .The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus Jean-Philippe Barnier ...
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Congratulation to Audrey LAURENT, Clémence MOUVILLE and Xiali FU

02/08/2021 .Audrey LAURENT and Clémence MOUVILLE have been awarded a PhD Track Grant from BioSPC. Xiali FU has been awarded ...
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PLOS Pathogen Barnier et al 2021

Type IV pilus retraction enables sustained bacteremia

Le 19/02/2021 .Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis ...
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Team Members

Last Publications

  1. de Cacqueray, N, Hirt, D, Zheng, Y, Bille, E, Leger, PL, Rambaud, J et al.. Cefepime population pharmacokinetics and dosing regimen optimization in critically ill children with different renal function. Clin Microbiol Infect. 2022; :. doi: 10.1016/j.cmi.2022.05.007. PubMed PMID:35605841 .
  2. Farfour, E, Dortet, L, Guillard, T, Chatelain, N, Poisson, A, Mizrahi, A et al.. Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France. Pathogens. 2022;11 (3):. doi: 10.3390/pathogens11030356. PubMed PMID:35335681 PubMed Central PMC8949168.
  3. de Cacqueray, N, Boujaafar, S, Bille, E, Moulin, F, Gana, I, Benaboud, S et al.. Therapeutic Drug Monitoring of Antibiotics in Critically Ill Children: An Observational Study in a Pediatric Intensive Care Unit. Ther Drug Monit. 2022;44 (2):319-327. doi: 10.1097/FTD.0000000000000918. PubMed PMID:35292609 .
  4. Beauruelle, C, Plouzeau, C, Grillon, A, Isnard, C, Corvec, S, Degand, N et al.. Capnocytophaga zoonotic infections: a 10-year retrospective study (the French CANCAN study). Eur J Clin Microbiol Infect Dis. 2022;41 (4):581-588. doi: 10.1007/s10096-022-04402-x. PubMed PMID:35064380 .
  5. Lombes, A, Bonnin, RA, Laurent, F, Guet-Revillet, H, Bille, E, Cattoir, V et al.. High Prevalence of OXA-23 Carbapenemase-Producing Proteus mirabilis among Amoxicillin-Clavulanate-Resistant Isolates in France. Antimicrob Agents Chemother. 2022;66 (2):e0198321. doi: 10.1128/AAC.01983-21. PubMed PMID:34930033 PubMed Central PMC8846483.
  6. Tinévez, C, Velardo, F, Ranc, AG, Dubois, D, Pailhoriès, H, Codde, C et al.. Retrospective multicentric study on Campylobacter spp. bacteremia in France: the Campylobacteremia study. Clin Infect Dis. 2021; :. doi: 10.1093/cid/ciab983. PubMed PMID:34849656 .
  7. Barnier, JP, Meyer, J, Kolappan, S, Bouzinba-Ségard, H, Gesbert, G, Jamet, A et al.. The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci U S A. 2021;118 (45):. doi: 10.1073/pnas.2109364118. PubMed PMID:34725157 PubMed Central PMC8609321.
  8. Runyo, F, Beaudoin, MC, Hammadi, B, Morgand, M, Driessen, M, Sellier, Y et al.. Procalcitonin use for the screening of bacterial infections in pregnant women in the emergency ward: A prospective study. J Infect. 2021;83 (3):e4-e5. doi: 10.1016/j.jinf.2021.07.005. PubMed PMID:34271061 .
  9. Medjebeur Hanna, R, Levy, M, Bille, E, Hennequin, C, Lesage, F, Naudin, J et al.. Assessment of the Effects of a High Amikacin Dose on Plasma Peak Concentration in Critically Ill Children. Paediatr Drugs. 2021;23 (4):395-401. doi: 10.1007/s40272-021-00456-0. PubMed PMID:34142330 .
  10. Farfour, E, Si Larbi, AG, Cattoir, V, Corvec, S, Guillard, T, Grillon, A et al.. Temocillin susceptibility among Enterobacterales strains recovered from blood culture in France. Diagn Microbiol Infect Dis. 2021;100 (3):115368. doi: 10.1016/j.diagmicrobio.2021.115368. PubMed PMID:33813355 .
  11. Lefèvre, CR, Pelletier, R, Le Monnier, A, Corvec, S, Bille, E, Potron, A et al.. Clinical relevance and antimicrobial susceptibility profile of the unknown human pathogen Corynebacterium aurimucosum. J Med Microbiol. 2021;70 (3):. doi: 10.1099/jmm.0.001334. PubMed PMID:33734955 .
  12. Cormontagne, D, Rigourd, V, Vidic, J, Rizzotto, F, Bille, E, Ramarao, N et al.. Bacillus cereus Induces Severe Infections in Preterm Neonates: Implication at the Hospital and Human Milk Bank Level. Toxins (Basel). 2021;13 (2):. doi: 10.3390/toxins13020123. PubMed PMID:33562185 PubMed Central PMC7915446.
  13. Poline, J, Postaire, M, Parize, P, Pilmis, B, Bille, E, Zahar, JR et al.. Stewardship program on carbapenem prescriptions in a tertiary hospital for adults and children in France: a cohort study. Eur J Clin Microbiol Infect Dis. 2021;40 (5):1039-1048. doi: 10.1007/s10096-020-04103-3. PubMed PMID:33389261 PubMed Central PMC7778866.
  14. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 PubMed Central PMC8106705.
  15. Decalonne, M, Dos Santos, S, Gimenes, R, Goube, F, Abadie, G, Aberrane, S et al.. Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units. Eur J Clin Microbiol Infect Dis. 2020;39 (11):2185-2194. doi: 10.1007/s10096-020-03925-5. PubMed PMID:32519215 PubMed Central PMC7561542.
  16. Pilmis, B, Alby-Laurent, F, Fasola, ML, Seegers, V, Guery, R, Guet-Revillet, H et al.. Pseudomonas aeruginosa bloodstream infections in children: a 9-year retrospective study. Eur J Pediatr. 2020;179 (8):1247-1254. doi: 10.1007/s00431-020-03598-4. PubMed PMID:32080759 .
  17. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Author Correction: Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):17535. doi: 10.1038/s41598-019-54253-4. PubMed PMID:31754179 PubMed Central PMC6872590.
  18. Rapp, M, Urien, S, Foissac, F, Béranger, A, Bouazza, N, Benaboud, S et al.. Population pharmacokinetics of meropenem in critically ill children with different renal functions. Eur J Clin Pharmacol. 2020;76 (1):61-71. doi: 10.1007/s00228-019-02761-7. PubMed PMID:31654149 .
  19. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  20. Simonin, J, Bille, E, Crambert, G, Noel, S, Dreano, E, Edwards, A et al.. Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis. Sci Rep. 2019;9 (1):6516. doi: 10.1038/s41598-019-42751-4. PubMed PMID:31019198 PubMed Central PMC6482305.
  21. Brunel, M, Leclerc-Mercier, S, Barnier, JP, Bille, E, Sberro-Soussan, R, Legendre, C et al.. The Case | Posttransplant upper limb inflammatory nodules. Kidney Int. 2019;95 (3):721-722. doi: 10.1016/j.kint.2018.10.012. PubMed PMID:30784666 .
  22. Le Gallou, S, Zhou, Z, Thai, LH, Fritzen, R, de Los Aires, AV, Mégret, J et al.. A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses. J Exp Med. 2018;215 (8):2035-2053. doi: 10.1084/jem.20180977. PubMed PMID:29959173 PubMed Central PMC6080908.
  23. Béranger, A, Benaboud, S, Urien, S, Moulin, F, Bille, E, Lesage, F et al.. Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children with Normal and Augmented Renal Clearance. Clin Pharmacokinet. 2019;58 (2):223-233. doi: 10.1007/s40262-018-0682-1. PubMed PMID:29862466 .
  24. Bille, E, Meyer, J, Jamet, A, Euphrasie, D, Barnier, JP, Brissac, T et al.. A virulence-associated filamentous bacteriophage of Neisseria meningitidis increases host-cell colonisation. PLoS Pathog. 2017;13 (7):e1006495. doi: 10.1371/journal.ppat.1006495. PubMed PMID:28704569 PubMed Central PMC5526601.
  25. Capel, E, Zomer, AL, Nussbaumer, T, Bole, C, Izac, B, Frapy, E et al.. Comprehensive Identification of Meningococcal Genes and Small Noncoding RNAs Required for Host Cell Colonization. mBio. 2016;7 (4):. doi: 10.1128/mBio.01173-16. PubMed PMID:27486197 PubMed Central PMC4981724.
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