Mathieu Coureuil

Mathieu Coureuil is a senior scientist at the Necker-Enfants Malades Institute (« Chargé de Recherche », Inserm). He received his Ph.D. in Cell Biologogy from University Paris-Sud, France, in 2006. Since then, he studies the interaction between N. meningitidis and human endothelial cells. He demonstrated the role of the meningococcus induced endothelial cell signaling during invasion of human vessels.  His current discovery-driven research focuses on determining the molecular mechanisms involved in the endothelial cell colonization. Besides, Mathieu Coureuil developed a new thematic studying S. aureus in the context of chronic infections.
Currently, MC is interested in invasive meningococcal infections, from portal of entry to sepsis, as well as chronic S. aureus infections.

https://orcid.org/0000-0001-7655-9685
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Mathieu Coureuil

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Evidence for the activation of potassium export by cyclic di-AMP!
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c-di-AMP, a likely master regulator of bacterial K+ homeostasis machinery, activates a K+ exporter | PNAS https://www.pnas.org/content/118/14/e2020653118

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Last News of the Lab

PLOS Pathogen Barnier et al 2021

Type IV pilus retraction enables sustained bacteremia

Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model. Jean-Philippe Barnier et al PLOS Pathogen 2021 News linked to Mathieu Coureuil Neisseria meningitidis (the meningococcus) remains a major cause of bacterial meningitis and fatal sepsis. This commensal bacterium of the human ...
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JClinMicro_AJ2021

High resolution typing of Staphylococcus epidermidis

High resolution typing of Staphylococcus epidermidis based on cgMLST to investigate the hospital spread of multidrug resistant clones. Jamet et al J Clin Microbiol 2020 Dec 16 News linked to Anne Jame Staphylococcus epidermidis is a pathogen emerging worldwide as a leading cause of health-care associated infections. A standardized high-resolution typing method to document transmission ...
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Chronic Staphylococcus Aureus Lung Infection Correlates With an Increased Intracellular Persistence

Chronic Staphylococcus Aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence. Tan et al, Clin Infect Dis, 69 (11), 1937-1945 2019 Nov 13 News linked to Alain Charbit, Mathieu Coureuil & Anne Jamet Background: Chronic lung infection in cystic fibrosis (CF) patients by Staphylococcus aureus is a well-established epidemiological ...
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Team Members (Neisseria meningitidis)

Team Members (Staphylococcus aureus)

Grants and Funding

Call, funding agencyProject’s titleName of the scientific coordinatorStart - End
Paris EmergencesMolecular basis of signaling induced by Neisseria meningitidis on epithelial and endothelial cellMathieu Coureuil2011-2015
ANRMolecular basis of signaling induced by Neisseria meningitidis on epithelial and endothelial cellMathieu Coureuil2011-2014
ANRMechanisms of colonization and dissemination of a bacterial pathogen in a human population, the example of Neisseria meningitidisMathieu Coureuil2015-2020
Vaincre la mucoviscidoseStaphylococcus aureus infection in cystic fibrosisMathieu Coureuil2018-2019
Emergence program, Université de ParisStaphylococcus aureus infection in cystic fibrosisMathieu Coureuil2019-2020
ANRMechanical activation, dependent on carbohydrate, of the ß2-adrenergic rfeceptorStefano Marullo2020-2023

Last 25 Publications

  1. Barnier, JP, Euphrasie, D, Join-Lambert, O, Audry, M, Schonherr-Hellec, S, Schmitt, T et al.. Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model. PLoS Pathog. 2021;17 (2):e1009299. doi: 10.1371/journal.ppat.1009299. PubMed PMID:33592056 PubMed Central PMC7909687.
  2. Rytter, H, Jamet, A, Coureuil, M, Charbit, A, Ramond, E. Which Current and Novel Diagnostic Avenues for Bacterial Respiratory Diseases?. Front Microbiol. 2020;11 :616971. doi: 10.3389/fmicb.2020.616971. PubMed PMID:33362754 PubMed Central PMC7758241.
  3. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 .
  4. Marullo, S, Doly, S, Saha, K, Enslen, H, Scott, MGH, Coureuil, M et al.. Mechanical GPCR Activation by Traction Forces Exerted on Receptor N-Glycans. ACS Pharmacol Transl Sci. 2020;3 (2):171-178. doi: 10.1021/acsptsci.9b00106. PubMed PMID:32296760 PubMed Central PMC7155188.
  5. Dos Santos Souza, I, Maïssa, N, Ziveri, J, Morand, PC, Coureuil, M, Nassif, X et al.. Meningococcal disease: A paradigm of type-IV pilus dependent pathogenesis. Cell Microbiol. 2020;22 (4):e13185. doi: 10.1111/cmi.13185. PubMed PMID:32185901 .
  6. Le Guennec, L, Virion, Z, Bouzinba-Ségard, H, Robbe-Masselot, C, Léonard, R, Nassif, X et al.. Receptor recognition by meningococcal type IV pili relies on a specific complex N-glycan. Proc Natl Acad Sci U S A. 2020;117 (5):2606-2612. doi: 10.1073/pnas.1919567117. PubMed PMID:31964828 PubMed Central PMC7007569.
  7. Audry, M, Robbe-Masselot, C, Barnier, JP, Gachet, B, Saubaméa, B, Schmitt, A et al.. Airway Mucus Restricts Neisseria meningitidis Away from Nasopharyngeal Epithelial Cells and Protects the Mucosa from Inflammation. mSphere. 2019;4 (6):. doi: 10.1128/mSphere.00494-19. PubMed PMID:31801841 PubMed Central PMC6893211.
  8. Tan, X, Coureuil, M, Charbit, A, Jamet, A. Multitasking Actors of Staphylococcus aureus Metabolism and Virulence. Trends Microbiol. 2020;28 (1):6-9. doi: 10.1016/j.tim.2019.10.013. PubMed PMID:31753539 .
  9. Ramond, E, Jamet, A, Coureuil, M, Charbit, A. Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens. Front Immunol. 2019;10 :2461. doi: 10.3389/fimmu.2019.02461. PubMed PMID:31708919 PubMed Central PMC6819784.
  10. Le Guennec, L, Coureuil, M, Nassif, X, Bourdoulous, S. Strategies used by bacterial pathogens to cross the blood-brain barrier. Cell Microbiol. 2020;22 (1):e13132. doi: 10.1111/cmi.13132. PubMed PMID:31658405 .
  11. Virion, Z, Doly, S, Saha, K, Lambert, M, Guillonneau, F, Bied, C et al.. Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili. Nat Commun. 2019;10 (1):4752. doi: 10.1038/s41467-019-12685-6. PubMed PMID:31628314 PubMed Central PMC6800425.
  12. Ziveri, J, Chhuon, C, Jamet, A, Rytter, H, Prigent, G, Tros, F et al.. Critical Role of a Sheath Phosphorylation Site On the Assembly and Function of an Atypical Type VI Secretion System. Mol Cell Proteomics. 2019;18 (12):2418-2432. doi: 10.1074/mcp.RA119.001532. PubMed PMID:31578219 PubMed Central PMC6885697.
  13. Tan, X, Ramond, E, Jamet, A, Barnier, JP, Decaux-Tramoni, B, Dupuis, M et al.. Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection. J Infect Dis. 2019;220 (12):1967-1976. doi: 10.1093/infdis/jiz404. PubMed PMID:31420648 .
  14. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  15. Virion, Z, Marullo, S, Coureuil, M. Methods to Study the Roles of β-Arrestins in Meningococcal Signaling. Methods Mol Biol. 2019;1957 :325-334. doi: 10.1007/978-1-4939-9158-7_20. PubMed PMID:30919363 .
  16. Denis, K, Le Bris, M, Le Guennec, L, Barnier, JP, Faure, C, Gouge, A et al.. Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease. Nat Microbiol. 2019;4 (6):972-984. doi: 10.1038/s41564-019-0395-8. PubMed PMID:30911127 .
  17. Tan, X, Coureuil, M, Ramond, E, Euphrasie, D, Dupuis, M, Tros, F et al.. Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence. Clin Infect Dis. 2019;69 (11):1937-1945. doi: 10.1093/cid/ciz106. PubMed PMID:30753350 .
  18. Lécuyer, H, Nassif, X, Coureuil, M. [Meningococcus purpura fulminans, a partially solved mystery]. Med Sci (Paris). 2018;34 (12):1038-1041. doi: 10.1051/medsci/2018288. PubMed PMID:30623761 .
  19. Lécuyer, H, Virion, Z, Barnier, JP, Matczak, S, Bourdoulous, S, Bianchini, E et al.. An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. PLoS Pathog. 2018;14 (4):e1006981. doi: 10.1371/journal.ppat.1006981. PubMed PMID:29630665 PubMed Central PMC5908201.
  20. Capel, E, Barnier, JP, Zomer, AL, Bole-Feysot, C, Nussbaumer, T, Jamet, A et al.. Peripheral blood vessels are a niche for blood-borne meningococci. Virulence. 2017;8 (8):1808-1819. doi: 10.1080/21505594.2017.1391446. PubMed PMID:29099305 PubMed Central PMC5810509.
  21. Wang, F, Coureuil, M, Osinski, T, Orlova, A, Altindal, T, Gesbert, G et al.. Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution. Structure. 2017;25 (9):1423-1435.e4. doi: 10.1016/j.str.2017.07.016. PubMed PMID:28877506 .
  22. Maïssa, N, Covarelli, V, Janel, S, Durel, B, Simpson, N, Bernard, SC et al.. Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4. Nat Commun. 2017;8 :15764. doi: 10.1038/ncomms15764. PubMed PMID:28569760 PubMed Central PMC5461506.
  23. Lécuyer, H, Borgel, D, Nassif, X, Coureuil, M. Pathogenesis of meningococcal purpura fulminans. Pathog Dis. 2017;75 (3):. doi: 10.1093/femspd/ftx027. PubMed PMID:28334263 .
  24. Coureuil, M, Lécuyer, H, Bourdoulous, S, Nassif, X. A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers. Nat Rev Microbiol. 2017;15 (3):149-159. doi: 10.1038/nrmicro.2016.178. PubMed PMID:28090076 .
  25. Kolappan, S, Coureuil, M, Yu, X, Nassif, X, Egelman, EH, Craig, L et al.. Structure of the Neisseria meningitidis Type IV pilus. Nat Commun. 2016;7 :13015. doi: 10.1038/ncomms13015. PubMed PMID:27698424 PubMed Central PMC5059446.
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