Mathieu Coureuil

Mathieu Coureuil is a senior scientist at the Necker-Enfants Malades Institute (« Chargé de Recherche », Inserm). He received his Ph.D. in Cell Biology from University Paris-Sud, France, in 2006. Since then, he studies the interaction between N. meningitidis and human endothelial cells. He demonstrated the role of the meningococcus induced endothelial cell signaling during invasion of human vessels.  His current discovery-driven research focuses on determining the molecular mechanisms involved in the endothelial cell colonization. Besides, Mathieu Coureuil developed a new thematic studying S. aureus in the context of chronic infections.
Currently, MC is interested in invasive meningococcal infections, from portal of entry to sepsis, as well as chronic S. aureus infections.

https://orcid.org/0000-0001-7655-9685
ResearchGate

Mathieu Coureuil

Fresh from the oven! Today in @jlb_journal
Dysregulation of the IFN-I signaling pathway by M. tuberculosis leads to exacerbation of HIV-1 infection of macrophages
Congrats to Maeva Dupont (not on Twitter? 🤔) @GClugo @ChrisVerollet and the gang! 👏👏👏
https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.4MA0422-730R

Proud to announce our new paper with @Shaevitz and @Gitai1!
We show that bacteria can sense substrate stiffness and reveal an exciting link between bacterial virulence and mechanical properties of the infection site!
1/n
https://www.pnas.org/doi/10.1073/pnas.2119434119

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Last News of the Lab

Barnier_PNAS2021

The minor pilin PilV is necessary for meningococcal type IV pilus adhesion

12/11/2021 .The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus Jean-Philippe Barnier et al PNAS 2021 Neisseria meningitidis utilizes type IV pili (T4P) to adhere to and colonize host endothelial cells, a process at the heart of meningococcal invasive diseases leading to meningitis and sepsis. T4P are ...
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The pentose phosphate pathway in pathogenic Francisella

03/08/2021 .The pentose phosphate pathway constitutes a major metabolic hub in pathogenic FrancisellaHéloise Rytter et al PLOS Pathogens 2021. Metabolic pathways are now considered as intrinsic virulence attributes of pathogenic bacteria and thus represent potential targets for antibacterial strategies. Here we focused on the role of the pentose phosphate pathway (PPP) and its connections with ...
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Congratulation to Audrey LAURENT, Clémence MOUVILLE and Xiali FU

02/08/2021 .Audrey LAURENT and Clémence MOUVILLE have been awarded a PhD Track Grant from BioSPC. Xiali FU has been awarded a PhD Track Grant from China Scholarship Council. We are all very proud and very excited about the science to come. Audrey will work on Neisseria meningitidis and host-cell membrane. Clémence will work on Neisseria ...
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Grants and Funding

Call, funding agencyProject’s titleName of the scientific coordinatorStart - End
Paris EmergencesMolecular basis of signaling induced by Neisseria meningitidis on epithelial and endothelial cellMathieu Coureuil2011-2015
ANRMolecular basis of signaling induced by Neisseria meningitidis on epithelial and endothelial cellMathieu Coureuil2011-2014
ANRMechanisms of colonization and dissemination of a bacterial pathogen in a human population, the example of Neisseria meningitidisMathieu Coureuil2015-2020
Vaincre la mucoviscidoseStaphylococcus aureus infection in cystic fibrosisMathieu Coureuil2018-2019
Emergence program, Université de ParisStaphylococcus aureus infection in cystic fibrosisMathieu Coureuil2019-2020
ANRMechanical activation, dependent on carbohydrate, of the ß2-adrenergic rfeceptorStefano Marullo2020-2023
Emergence program, Université de ParisStaphylococcus aureus infection in cystic fibrosis - Follow upMathieu Coureuil2021-2022

Last 25 Publications

  1. Marullo, S, Scott, MGH, Enslen, H, Coureuil, M. Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe Can Reveal Signalling Pathways in Endothelial Cells, and a Unique Mode of Receptor Activation Involving Its N-Terminal Glycan Chains. Front Endocrinol (Lausanne). 2022;13 :883568. doi: 10.3389/fendo.2022.883568. PubMed PMID:35586623 PubMed Central PMC9108228.
  2. Ramond, E, Lepissier, A, Ding, X, Bouvier, C, Tan, X, Euphrasie, D et al.. Lung-adapted Staphylococcus aureus isolates with dysfunctional agr system trigger a proinflammatory response. J Infect Dis. 2022; :. doi: 10.1093/infdis/jiac191. PubMed PMID:35524969 .
  3. Barroca, V, Racine, C, Pays, L, Fouchet, P, Coureuil, M, Allemand, I et al.. The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice. Stem Cell Res. 2022;60 :102723. doi: 10.1016/j.scr.2022.102723. PubMed PMID:35247845 .
  4. Barnier, JP, Meyer, J, Kolappan, S, Bouzinba-Ségard, H, Gesbert, G, Jamet, A et al.. The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci U S A. 2021;118 (45):. doi: 10.1073/pnas.2109364118. PubMed PMID:34725157 PubMed Central PMC8609321.
  5. Rytter, H, Jamet, A, Ziveri, J, Ramond, E, Coureuil, M, Lagouge-Roussey, P et al.. The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella. PLoS Pathog. 2021;17 (8):e1009326. doi: 10.1371/journal.ppat.1009326. PubMed PMID:34339477 PubMed Central PMC8360588.
  6. Ramond, E, Jamet, A, Ding, X, Euphrasie, D, Bouvier, C, Lallemant, L et al.. Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the Drosophila Larval Model. mBio. 2021;12 (3):e0027621. doi: 10.1128/mBio.00276-21. PubMed PMID:34126772 PubMed Central PMC8262968.
  7. Barnier, JP, Euphrasie, D, Join-Lambert, O, Audry, M, Schonherr-Hellec, S, Schmitt, T et al.. Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model. PLoS Pathog. 2021;17 (2):e1009299. doi: 10.1371/journal.ppat.1009299. PubMed PMID:33592056 PubMed Central PMC7909687.
  8. Rytter, H, Jamet, A, Coureuil, M, Charbit, A, Ramond, E. Which Current and Novel Diagnostic Avenues for Bacterial Respiratory Diseases?. Front Microbiol. 2020;11 :616971. doi: 10.3389/fmicb.2020.616971. PubMed PMID:33362754 PubMed Central PMC7758241.
  9. Jamet, A, Guglielmini, J, Brancotte, B, Coureuil, M, Euphrasie, D, Meyer, J et al.. High-Resolution Typing of Staphylococcus epidermidis Based on Core Genome Multilocus Sequence Typing To Investigate the Hospital Spread of Multidrug-Resistant Clones. J Clin Microbiol. 2021;59 (3):. doi: 10.1128/JCM.02454-20. PubMed PMID:33328176 PubMed Central PMC8106705.
  10. Marullo, S, Doly, S, Saha, K, Enslen, H, Scott, MGH, Coureuil, M et al.. Mechanical GPCR Activation by Traction Forces Exerted on Receptor N-Glycans. ACS Pharmacol Transl Sci. 2020;3 (2):171-178. doi: 10.1021/acsptsci.9b00106. PubMed PMID:32296760 PubMed Central PMC7155188.
  11. Dos Santos Souza, I, Maïssa, N, Ziveri, J, Morand, PC, Coureuil, M, Nassif, X et al.. Meningococcal disease: A paradigm of type-IV pilus dependent pathogenesis. Cell Microbiol. 2020;22 (4):e13185. doi: 10.1111/cmi.13185. PubMed PMID:32185901 .
  12. Le Guennec, L, Virion, Z, Bouzinba-Ségard, H, Robbe-Masselot, C, Léonard, R, Nassif, X et al.. Receptor recognition by meningococcal type IV pili relies on a specific complex N-glycan. Proc Natl Acad Sci U S A. 2020;117 (5):2606-2612. doi: 10.1073/pnas.1919567117. PubMed PMID:31964828 PubMed Central PMC7007569.
  13. Audry, M, Robbe-Masselot, C, Barnier, JP, Gachet, B, Saubaméa, B, Schmitt, A et al.. Airway Mucus Restricts Neisseria meningitidis Away from Nasopharyngeal Epithelial Cells and Protects the Mucosa from Inflammation. mSphere. 2019;4 (6):. doi: 10.1128/mSphere.00494-19. PubMed PMID:31801841 PubMed Central PMC6893211.
  14. Tan, X, Coureuil, M, Charbit, A, Jamet, A. Multitasking Actors of Staphylococcus aureus Metabolism and Virulence. Trends Microbiol. 2020;28 (1):6-9. doi: 10.1016/j.tim.2019.10.013. PubMed PMID:31753539 .
  15. Ramond, E, Jamet, A, Coureuil, M, Charbit, A. Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens. Front Immunol. 2019;10 :2461. doi: 10.3389/fimmu.2019.02461. PubMed PMID:31708919 PubMed Central PMC6819784.
  16. Le Guennec, L, Coureuil, M, Nassif, X, Bourdoulous, S. Strategies used by bacterial pathogens to cross the blood-brain barrier. Cell Microbiol. 2020;22 (1):e13132. doi: 10.1111/cmi.13132. PubMed PMID:31658405 .
  17. Virion, Z, Doly, S, Saha, K, Lambert, M, Guillonneau, F, Bied, C et al.. Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili. Nat Commun. 2019;10 (1):4752. doi: 10.1038/s41467-019-12685-6. PubMed PMID:31628314 PubMed Central PMC6800425.
  18. Ziveri, J, Chhuon, C, Jamet, A, Rytter, H, Prigent, G, Tros, F et al.. Critical Role of a Sheath Phosphorylation Site On the Assembly and Function of an Atypical Type VI Secretion System. Mol Cell Proteomics. 2019;18 (12):2418-2432. doi: 10.1074/mcp.RA119.001532. PubMed PMID:31578219 PubMed Central PMC6885697.
  19. Tan, X, Ramond, E, Jamet, A, Barnier, JP, Decaux-Tramoni, B, Dupuis, M et al.. Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection. J Infect Dis. 2019;220 (12):1967-1976. doi: 10.1093/infdis/jiz404. PubMed PMID:31420648 .
  20. Coureuil, M, Jamet, A, Bille, E, Lécuyer, H, Bourdoulous, S, Nassif, X et al.. Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol. 2019;21 (11):e13063. doi: 10.1111/cmi.13063. PubMed PMID:31167044 PubMed Central PMC6899865.
  21. Virion, Z, Marullo, S, Coureuil, M. Methods to Study the Roles of β-Arrestins in Meningococcal Signaling. Methods Mol Biol. 2019;1957 :325-334. doi: 10.1007/978-1-4939-9158-7_20. PubMed PMID:30919363 .
  22. Denis, K, Le Bris, M, Le Guennec, L, Barnier, JP, Faure, C, Gouge, A et al.. Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease. Nat Microbiol. 2019;4 (6):972-984. doi: 10.1038/s41564-019-0395-8. PubMed PMID:30911127 .
  23. Tan, X, Coureuil, M, Ramond, E, Euphrasie, D, Dupuis, M, Tros, F et al.. Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence. Clin Infect Dis. 2019;69 (11):1937-1945. doi: 10.1093/cid/ciz106. PubMed PMID:30753350 .
  24. Lécuyer, H, Nassif, X, Coureuil, M. [Meningococcus purpura fulminans, a partially solved mystery]. Med Sci (Paris). 2018;34 (12):1038-1041. doi: 10.1051/medsci/2018288. PubMed PMID:30623761 .
  25. Lécuyer, H, Virion, Z, Barnier, JP, Matczak, S, Bourdoulous, S, Bianchini, E et al.. An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. PLoS Pathog. 2018;14 (4):e1006981. doi: 10.1371/journal.ppat.1006981. PubMed PMID:29630665 PubMed Central PMC5908201.
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