Sophia Schönherr-Hellec

Sophia Schönherr-Hellec is a post-doctoral researcher at the Necker-Enfants Malades Institute. She received her PhD in Microbiology from Paris Descartes University, France, in 2017. During her PhD she performed a comparative analysis of the characteristics of clinical strains of Clostiridum neonatale and Clostridium butyricum isolated from premature neonates with or without necrotizing enterocloitis and reported for the first time a specific bacterial signature potentially linked with this intestinal disease. Sophia joined the Neisseria meningitidis team in 2018 and studies the interaction between N. meningitidis and human endothelial cells under the supervision of Mathieu Coureuil.


Last News of the Lab

Mechanical Activation of the β2-Adrenergic Receptor by Meningococci (Review)

02/05/2022 .Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe ...
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Barnier_PNAS2021

The minor pilin PilV is necessary for meningococcal type IV pilus adhesion

12/11/2021 .The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus Jean-Philippe Barnier ...
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Congratulation to Audrey LAURENT, Clémence MOUVILLE and Xiali FU

02/08/2021 .Audrey LAURENT and Clémence MOUVILLE have been awarded a PhD Track Grant from BioSPC. Xiali FU has been awarded ...
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Last Publications

  1. Barnier, JP, Meyer, J, Kolappan, S, Bouzinba-Ségard, H, Gesbert, G, Jamet, A et al.. The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci U S A. 2021;118 (45):. doi: 10.1073/pnas.2109364118. PubMed PMID:34725157 PubMed Central PMC8609321.
  2. Barnier, JP, Euphrasie, D, Join-Lambert, O, Audry, M, Schonherr-Hellec, S, Schmitt, T et al.. Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model. PLoS Pathog. 2021;17 (2):e1009299. doi: 10.1371/journal.ppat.1009299. PubMed PMID:33592056 PubMed Central PMC7909687.
  3. Audry, M, Robbe-Masselot, C, Barnier, JP, Gachet, B, Saubaméa, B, Schmitt, A et al.. Airway Mucus Restricts Neisseria meningitidis Away from Nasopharyngeal Epithelial Cells and Protects the Mucosa from Inflammation. mSphere. 2019;4 (6):. doi: 10.1128/mSphere.00494-19. PubMed PMID:31801841 PubMed Central PMC6893211.
  4. Schönherr-Hellec, S, Aires, J. Clostridia and necrotizing enterocolitis in preterm neonates. Anaerobe. 2019;58 :6-12. doi: 10.1016/j.anaerobe.2019.04.005. PubMed PMID:30980889 .
  5. Schönherr-Hellec, S, Klein, GL, Delannoy, J, Ferraris, L, Rozé, JC, Butel, MJ et al.. Clostridial Strain-Specific Characteristics Associated with Necrotizing Enterocolitis. Appl Environ Microbiol. 2018;84 (7):. doi: 10.1128/AEM.02428-17. PubMed PMID:29352082 PubMed Central PMC5861827.
  6. Schönherr-Hellec, S, Klein, G, Delannoy, J, Ferraris, L, Friedel, I, Rozé, JC et al.. Comparative phenotypic analysis of "Clostridium neonatale" and Clostridium butyricum isolates from neonates. Anaerobe. 2017;48 :76-82. doi: 10.1016/j.anaerobe.2017.07.002. PubMed PMID:28739338 .
  7. Landreau, M, Duthoit, F, Roussel, E, Schönherr, S, Georges, M, Godfroy, A et al.. Cultivation of an immobilized (hyper)thermophilic marine microbial community in a bioreactor. FEMS Microbiol Lett. 2016;363 (17):. doi: 10.1093/femsle/fnw194. PubMed PMID:27528693 .
  8. Ferraris, L, Schönherr, S, Bouvet, P, Dauphin, B, Popoff, M, Butel, MJ et al.. One-Step Multiplex PCR Assay for Differentiating Proposed New Species "Clostridium neonatale" from Closely Related Species. J Clin Microbiol. 2015;53 (11):3621-3. doi: 10.1128/JCM.01404-15. PubMed PMID:26292306 PubMed Central PMC4609713.
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